Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmericam. DIABFRAIL-LATAM: DR. JOSÉ VIÑA 2018

Datos básicos

Protocolo:
825546
EUDRACT:
NCT:
Centro:
Año de incio:
2019
Año de finalización:
2024
PROYECTO DE INVESTIGACIÓN EUROPEA F.COMPETITIVA FIN. PUBLICA 155.150,00 €

Documentos

  • No hay documentos

Participantes

Grupos y Plataformas de I+D+i

Financiadores - Promotores

EUROPEAN COMMISSION

Resultados del Ensayo Clínico


Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease.

Esteve, Daniel; (...); Lloret, Ana

Article. 10.1007/s12035-021-02620-6. 2022


Anti-Inflammatory Properties of Diet: Role in Healthy Aging.

Stromsnes, Kristine; (...); Olaso-Gonzalez, Gloria

Article. 10.3390/biomedicines9080922. 2021


Bcl-xL as a Modulator of Senescence and Aging.

Mas-Bargues, Cristina, Borras, Consuelo, Vina, Jose

Article. 10.3390/ijms22041527. 2021


Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice

Article. 10.1126/sciadv.adr1378. 2025

  • Open Access.

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

Borras, C; (...); Vina, J

Review. 10.3390/ijms21020418. 2020


Centenarians: An excellent example of resilience for successful ageing

Borras, C; (...); Vina, J

Review. 10.1016/j.mad.2019.111199. 2020


Diet and exercise in frailty and sarcopenia. Molecular aspects.

Millan-Domingo F; (...); Gomez-Cabrera MC

Article. 10.1016/j.mam.2024.101322. 2024

  • Open Access.

Early reductive stress and late onset overexpression of antioxidant enzymes in experimental myocardial infarction

Carretero, A; (...); Vina, J

Article. 10.1080/10715762.2020.1735632. 2020


Estrogen Replacement Therapy Induces Antioxidant and Longevity-Related Genes in Women after Medically Induced Menopause.

Borras, C; (...); Vina, J

Article. 10.1155/2021/8101615. 2021


Extracellular vesicles and redox modulation in aging.

Borras, Consuelo; (...); Vina, Jose

Review. 10.1016/j.freeradbiomed.2019.11.032. 2020


FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.

Garcia-Recio, Susana; (...); Perou, Charles M

Article. 10.1172/JCI130323. 2020


Functional Transcriptomic Analysis of Centenarians' Offspring Reveals a Specific Genetic Footprint That May Explain That They Are Less Frail Than Age-Matched Noncentenarians' Offspring.

Ingles, Marta; (...); Vina, Jose

Article. 10.1093/gerona/glac119. 2022


Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial.

Vina, J; (...); Borras, C

Article. 10.1186/s13195-022-01097-2. 2022


Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer's Disease Patients.

Viña J, Borrás C, Mas-Bargues C

Article. 10.3233/JAD-240308. 2024


Genistein, a tool for geroscience

Article. 10.1016/j.mad.2022.111665. 2022


Glucosamine Supplementation Improves Physical Performance in Trained Mice.

De la Rosa, Adrian; (...); Vina, Jose

Article. 10.1249/MSS.0000000000002821. 2022


Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer's disease.

Correas, AG; (...); Viña, J

Article. 10.1016/j.redox.2024.103242. 2024

  • Open Access.

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

Arc-Chagnaud, Coralie; (...); Carmen Gomez-Cabrera, Mari

Article. 10.1002/jcsm.12792. 2021

  • Open Access.

Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise.

Garcia-Dominguez, E; (...); Gomez-Cabrera, MC

Article. 10.3390/cells11193041. 2022


Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus.

Borras, C; (...); Vina, J

Article. 10.1016/j.mad.2021.111596. 2021


Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease.

Mas-Bargues, Cristina; (...); Vina, Jose

Article. 10.1016/j.abb.2021.108941. 2021


Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster.

Gambini, J; (...); Vina, J

Article. 10.3390/antiox10020301. 2021


Modulating Oxidant Levels to Promote Healthy Aging

Vina, J; (...); Gomez-Cabrera, MC

Article. 10.1089/ars.2020.8036. 2020


Molecular mechanisms of cancer cachexia. Role of exercise training.

Tamayo-Torres, E; (...); Gómez-Cabrera, MC

Article. 10.1016/j.mam.2024.101293. 2024

  • Open Access.

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction.

Roman, William; (...); Munoz-Canoves, Pura

Article. 10.1126/science.abe5620. 2021


Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Costa-Machado, Luis Filipe; (...); Fernandez-Marcos, Pablo J

Article. 10.1038/s41467-023-38410-y. 2023


Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans.

Stromsnes, Kristine; (...); Gambini, Juan

Article. 10.3390/biomedicines9081074. 2021

  • Open Access.

Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity

Article. 10.1111/acel.14429. 2025

  • Open Access.

Redox modulation of muscle mass and function.

Gomez-Cabrera, M C; (...); Vina, J

Article. 10.1016/j.redox.2020.101531. 2020


Redox-related biomarkers in physical exercise.

Gomez-Cabrera, MC; (...); Vina, J

Article. 10.1016/j.redox.2021.101956. 2021


Relation Between Genetic Factors and Frailty in Older Adults.

Ingles, Marta; (...); Vina, Jose

Article. 10.1016/j.jamda.2019.03.011. 2019


Residual effects of 12 weeks of power-oriented resistance training plus high-intensity interval training on muscle dysfunction, systemic oxidative damage, and antioxidant capacity after 10 months of training cessation in older people with COPD

Baltasar-Fernandez, Ivan; (...); Alcazar, Julian

Article. 10.1111/sms.14428. 2023


Resveratrol shifts energy metabolism to increase lipid oxidation in healthy old mice

Gimeno-Mallench, L; (...); Vina, J

Article. 10.1016/j.biopha.2019.109130. 2019


Serum Levels of Clusterin, PKR, and RAGE Correlate with Amyloid Burden in Alzheimer's Disease.

Monllor, Paloma; (...); Vina, Jose

Article. 10.3233/JAD-201443. 2021


Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

Sanz-Ros, Jorge; (...); Borras, Consuelo

Article. 10.1126/sciadv.abq2226. 2022


The multimodal action of genistein in Alzheimer's and other age-related diseases.

Mas-Bargues, Cristina, Borras, Consuelo, Vina, Jose

Article. 10.1016/j.freeradbiomed.2022.03.021. 2022


The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening.

Marques P; (...); Sanz MJ

Article. 10.3389/fmed.2022.871714. 2022


Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan.

Viña, J, Borrás, C

Article. 10.1002/1873-3468.14963. 2024

  • Open Access.

Campos de Estudio

Compartir