Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan.

Fecha de publicación: 01/09/2024 Fecha Ahead of Print: 02/07/2024

Autores de INCLIVA

• 

  Jose Viña Ribes

  Autor

• 

  Consuelo Borras Blasco

  Autor

Grupos y Plataformas de I+D+i

• Grupo de Investigación en Envejecimiento Saludable

  

  Leading Researcher

  Consuelo Borras Blasco

• Grupo de investigación en envejecimiento y ejercicio físico

  

  Leading Researcher

  Jose Viña Ribes

Abstract

In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. This review examines the link between mitochondrial function and aging, highlighting the importance of healthspan alongside lifespan. This involves significant human and economic challenges, with longer lifespans often accompanied by reduced well-being. Addressing mitochondrial decline, exploring targeted interventions, and understanding the complexities of research models are vital for advancing our knowledge in this field. Additionally, promoting physical exercise and adopting personalized supplementation strategies based on individual needs can contribute to healthy aging. The insights from this Perspective article offer a hopeful outlook for future advances in extending both lifespan and healthspan, aiming to improve the overall quality of life in aging populations.

© 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

Keywords

• healthspan; healthy aging intervention; lifespan; mitochondria; triage theory