Portal de investigación
The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) has placed enormous pressure on intensive care units (ICUs) and on healthcare systems in general. A deeper understanding of the pathophysiology of the most severe forms of COVID-19 would help guide the development of more effective interventions. Herein, we characterized the inflammatory state of patients with COVID-19 of varying degrees of severity to identify admission biomarkers for predicting COVID-19 worsening. DESIGN: Admission blood samples were obtained from 78 patients with COVID-19. Radiographic assessment of lung edema (RALE) scoring was calculated by imaging. Platelet and leukocyte counts were measured by flow cytometry, and plasma levels of C-reactive protein were assessed by immunoturbidimetry, and interleukin (IL)-8/CXCL8, IL-10, tumor necrosis factor (TNF)-a, interferon (IFN)-?, and monocyte chemoattractant protein-1 (MCP-1/CCL2) levels by enzyme-linked immunosorbent assay (ELISA). RESULTS: The RALE score correlated with several admission hemogram (platelets, neutrophils, and lymphocytes) and inflammatory (IL-8/CXCL8, MCP-1/CCL2, IL-10, and C-reactive protein) parameters. COVID-19 worsening, based on the need for oxygen ( oxygen supply) during hospitalization, correlated negatively with admission lymphocyte counts but positively with neutrophil-to-lymphocyte ratio and with plasma levels of the inflammatory parameters correlating with RALE score. CONCLUSION: Our data indicate a correlation between the RALE score and oxygen supply and admission inflammatory status. The identification of a panel of biomarkers that reflect COVID severity might be useful to predict disease worsening during hospitalization and to guide clinical management of COVID-19-related complications. Finally, therapies targeting IL-8/CXCL8- or IL-10 activity may offer therapeutic approaches in COVID-19 treatment.
Copyright © 2022 Marques, Fernandez-Presa, Carretero, Gómez-Cabrera, Viña, Signes-Costa and Sanz.
Datos de la publicación
- ISSN/ISSNe:
- 2296-858X, 2296-858X
- Tipo:
- Article
- Páginas:
- 871714-871714
- PubMed:
- 36035415
Frontiers in Medicine Frontiers Media S.A.
Citas Recibidas en Web of Science: 2
Documentos
Filiaciones
Keywords
- COVID-19; SARS-CoV-2; biomarkers; inflammation; rale score
Financiación
Proyectos y Estudios Clínicos
Identificación de nuevos mecanismos implicados en la angiogénesis e inflamación en pacientes obesos. Modulación por ligandos de receptores nucleares constitutivos de androstano.
Investigador Principal: LAURA PIQUERAS RUIZ
PI18/00209 . INSTITUTO SALUD CARLOS III . 2019
'Una aproximación translacional desde la clínica a la experimentación animal: Estudio del papel del eje CCL11/CCR3 y la inflamación eosinofílica en la patología cardiovascular asociada a desórdenes metabólicos. -
Investigador Principal: MARIA JESUS SANZ FERRANDO
PROMETEO2019/032 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2020
Cita
The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening. Marques P, 0000-0003-0728-5785, Carretero A, Gómez MC, Viña J, Signes J, Sanz MJ. Frontiers in Medicine. 2022 agosto 11. 9871714-871714. DOI:10.3389/fmed.2022.871714. PMID:36035415.
