Portal de investigación
Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Escriva, Consuelo
Grupos y Plataformas de I+D+i
Abstract
Free radicals and oxidants are involved in physiological signaling pathways, although an imbalance between pro-oxidant and anti-oxidant systems in favor of the former leads to major biomolecular damage. This is the so-called oxidative stress, a complex process that affects us all and is responsible for the development of many diseases. Lipids are very sensitive to oxidant attack and to-date, malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and F2-isoprostane are the main biomarkers for lipid peroxidation assessment. They all derive from polyunsaturated fatty acids (PUFAs) either by enzyme-catalyzed reactions (physiological) or by non-enzyme reactions (pathological). The profile of PUFAs present in the tissue will determine the proportion of each biomarker. In this review we aim to discuss the proper method for MDA determination using HPLC. We also offer reference MDA values in humans in physiological and pathological conditions.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0003-9861, 1096-0384
- Tipo:
- Article
- Páginas:
- 108941-108941
- PubMed:
- 34097903
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 218
Documentos
Filiaciones
Keywords
- 4-HNE; HPLC; Lipid peroxidation; MDA; Oxidative stress
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JOSE VIÑA RIBES
CB16/10/00435 . INSTITUTO SALUD CARLOS III
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Investigador Principal: JOSE VIÑA RIBES
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Cita
Mas C,Escriva C,Dromant M,Borras C,Vina J. Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Arch Biochem Biophys. 2021. 709. p. 108941-108941. IF:4,114. (2).
Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas C, Escriva C, Dromant M, Borras C, Vina J. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2021 septiembre 30. 709108941-108941. DOI:10.1016/j.abb.2021.108941. PMID:34097903.
