Portal de investigación
Diet and exercise in frailty and sarcopenia. Molecular aspects.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Grupos y Plataformas de I+D+i
Abstract
Function declines throughout life although phenotypical manifestations in terms of frailty or disability are only seen in the later periods of our life. The causes underlying lifelong function decline are the aging process "per se", chronic diseases, and lifestyle factors. These three etiological causes result in the deterioration of several organs and systems which act synergistically to finally produce frailty and disability. Regardless of the causes, the skeletal muscle is the main organ affected by developing sarcopenia. In the first section of the manuscript, as an introduction, we review the quantitative and qualitative age-associated skeletal muscle changes leading to frailty and sarcopenia and their impact in the quality of life and independence in the elderly. The reversibility of frailty and sarcopenia are discussed in the second and third sections of the manuscript. The most effective intervention to delay and even reverse frailty is exercise training. We review the role of different training programs (resistance exercise, cardiorespiratory exercise, multicomponent exercise, and real-life interventions) not only as a preventive but also as a therapeutical strategy to promote healthy aging. We also devote a section in the text to the sexual dimorphic effects of exercise training interventions in aging. How to optimize the skeletal muscle anabolic response to exercise training with nutrition is also discussed in our manuscript. The concept of anabolic resistance and the evidence of the role of high-quality protein, essential amino acids, creatine, vitamin D, ß-hydroxy-ß-methylbutyrate, and Omega-3 fatty acids, is reviewed. In the last section of the manuscript, the main genetic interventions to promote robustness in preclinical models are discussed. We aim to highlight the molecular pathways that are involved in frailty and sarcopenia. The possibility to effectively target these signaling pathways in clinical practice to delay muscle aging is also discussed.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0098-2997, 1872-9452
- Tipo:
- Article
- Páginas:
- 101322-101322
- PubMed:
- 39591800
MOLECULAR ASPECTS OF MEDICINE ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 6
Documentos
- No hay documentos
Filiaciones
Financiación
Proyectos y Estudios Clínicos
Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmericam. DIABFRAIL-LATAM: DR. JOSÉ VIÑA 2018
Investigador Principal: JOSE VIÑA RIBES
825546 . EUROPEAN COMMISSION . 2019
Cita
Millan F,Garcia E,Gambini J,Olaso G,Viña J,Gomez MC. Diet and exercise in frailty and sarcopenia. Molecular aspects. Mol Aspects Med. 2024. 100. p. 101322-101322. IF:10,300. (1).
Diet and exercise in frailty and sarcopenia. Molecular aspects. Millan F, Garcia E, Gambini J, Olaso G, Viña J, Gomez MC. MOLECULAR ASPECTS OF MEDICINE. 2024 diciembre 01. 100101322-101322. DOI:10.1016/j.mam.2024.101322. PMID:39591800.
