Portal de investigación
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Romero-Garcia, Nekane
- Gordevicius, Juozas
- Brooke, Robert T
- Derevyanko, Aksinya
- Guio-Carrion, Ana
- Blasco, Maria A
- Horvath, Steve
Grupos y Plataformas de I+D+i
Abstract
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement in several parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function, as well as an important decrease in frailty. ADSC-sEVs induced proregenerative effects and a decrease in oxidative stress, inflammation, and senescence markers in muscle and kidney. Moreover, predicted epigenetic age was lower in tissues of old mice treated with ADSC-sEVs and their metabolome changed to a youth-like pattern. Last, we gained some insight into the microRNAs contained in sEVs that might be responsible for the observed effects. We propose that young sEV treatment can promote healthy aging.
Datos de la publicación
- ISSN/ISSNe:
- 2375-2548, 2375-2548
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 36260670
Science Advances American Association for the Advancement of Science
Citas Recibidas en Web of Science: 79
Documentos
Filiaciones
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JOSE VIÑA RIBES
CB16/10/00435 . INSTITUTO SALUD CARLOS III
Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmericam. DIABFRAIL-LATAM: DR. JOSÉ VIÑA 2018
Investigador Principal: JOSE VIÑA RIBES
825546 . EUROPEAN COMMISSION . 2019
Cita
Sanz J,Romero N,Mas C,Monleon D,Gordevicius J,Brooke RT,Dromant M,Diaz A,Derevyanko A,Guio A,Roman A,Ingles M,Blasco MA,Horvath S,Vina J,Borras C. Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sci. Adv. 2022. 8. (42):eabq2226. IF:13,600. (1).
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sanz J, Romero N, Mas C, Monleon D, Gordevicius J, Brooke RT, Dromant M et al. Science Advances. 2022 octubre 21. 8 (42):DOI:10.1126/sciadv.abq2226. PMID:36260670.
