Portal de investigación
Modulating Oxidant Levels to Promote Healthy Aging
Autores de INCLIVA
Grupos y Plataformas de I+D+i
Abstract
Recent Advances: This review discusses the importance of the modulation of the oxidant levels through physiological strategies such as physical exercise or genetic manipulations such as the overexpression of antioxidant enzymes, in the promotion of healthy aging. Critical Issues: We have divided the review into five different sections. In the first two sections of the article "Oxidants are signals" and "Exercise training is an antioxidant," we discuss the main sources of free radicals during muscle contraction and their role, as hormetic substances, in the regulation of two main muscle adaptations to exercise in skeletal muscle; that is, mitochondrial biogenesis and the endogenous antioxidant defense. In the third section of the review, we deal with "the energy collapse in aging." The increased rate of reactive oxygen species (ROS) production and the low rate of mitochondria biosynthesis in the old cells are examined. Finally, in the fourth and fifth sections entitled "Overexpression of antioxidants enzymes in healthy aging" and "Exercise, longevity, and frailty," we consider the importance of the potentiation of the cellular defenses in health span and in life span. Future Directions: A correct manipulation of the ROS generation, directing these species to their physiological signaling role and preventing their deleterious effects, would allow the promotion of healthy aging.
Copyright 2020, Mary Ann Liebert, Inc., publishers
Datos de la publicación
- ISSN/ISSNe:
- 1523-0864, 1557-7716
- Tipo:
- Article
- Páginas:
- 570-579
- PubMed:
- 32008355
ANTIOXIDANTS & REDOX SIGNALING MARY ANN LIEBERT, INC
Citas Recibidas en Web of Science: 17
Documentos
- No hay documentos
Filiaciones
Keywords
- health span; skeletal muscle; exercise; glucose-6-phosphate dehydrogenase; mitochondria
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JOSE VIÑA RIBES
CB16/10/00435 . INSTITUTO SALUD CARLOS III
Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative
Investigador Principal: JOSE VIÑA RIBES
724099 . EUROPEAN COMMISSION . 2016
Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmericam. DIABFRAIL-LATAM: DR. JOSÉ VIÑA 2018
Investigador Principal: JOSE VIÑA RIBES
825546 . EUROPEAN COMMISSION . 2019
Cita
Vina J,Olaso G,Arc C,De la Rosa A,Gomez MC. Modulating Oxidant Levels to Promote Healthy Aging. Antioxid. Redox Signal. 2020. 33. (8):p. 570-579. IF:8,401. (1).
Modulating Oxidant Levels to Promote Healthy Aging. Vina J, Olaso G, Arc C, De la Rosa A, Gomez MC. ANTIOXIDANTS & REDOX SIGNALING. 2020 septiembre 10. 33 (8):570-579. DOI:10.1089/ars.2020.8036. PMID:32008355.
