Portal de investigación
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Abdelaziz, KM
- Jove, M
- Lopez-Grueso, R
- Pamplona, R
Grupos y Plataformas de I+D+i
Abstract
Soya consumption can decrease oxidative stress in animal models. Moreover, phytoestrogens such as genistein, present in soya, can mimic some of the beneficial effects of estrogens and are devoid of significant side effects, such as cancer. In this study, we have performed a controlled lifelong study with male OF1 mice that consumed either a soya-free diet or a soya-rich diet. We show that, although we found an increase in the expression and activity of antioxidant enzymes in soya-consuming mice, it did not increase lifespan. We reasoned that the soya diet could not increase lifespan in a very healthy population, but perhaps it could extend health span in stressed animals such as type 2 diabetic Goto Kakizaki (GK) rats. Indeed, this was the case: we found that male GK rats consuming a soya-rich diet developed the disease at a lower rate and, therefore, lived longer than soya-free diet-consuming rats.
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0047-6374, 1872-6216
- Tipo:
- Article
- Páginas:
- 111596-111596
- PubMed:
- 34774606
MECHANISMS OF AGEING AND DEVELOPMENT ELSEVIER IRELAND LTD
Citas Recibidas en Web of Science: 2
Documentos
Filiaciones
Keywords
- Antioxidant enzymes; Goto Kakizaki rats; Isoflavones; Longevity; Soya
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JOSE VIÑA RIBES
CB16/10/00435 . INSTITUTO SALUD CARLOS III
Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmericam. DIABFRAIL-LATAM: DR. JOSÉ VIÑA 2018
Investigador Principal: JOSE VIÑA RIBES
825546 . EUROPEAN COMMISSION . 2019
Cita
Borras C,Abdelaziz KM,Diaz A,Gambini J,Jove M,Lopez R,Mas C,Monleon D,Pamplona R,Vina J. Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Mech. Ageing Dev. 2021. 200. p. 111596-111596. IF:5,498. (2).
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez R, Mas C et al. MECHANISMS OF AGEING AND DEVELOPMENT. 2021 diciembre 01. 200111596-111596. DOI:10.1016/j.mad.2021.111596. PMID:34774606.
