Portal de investigación
Redox-related biomarkers in physical exercise.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Olaso-Gonzalez, G
Grupos y Plataformas de I+D+i
Abstract
Research in redox biology of exercise has made considerable advances in the last 70 years. Since the seminal study of George Pake's group calculating the content of free radicals in skeletal muscle in resting conditions in 1954, many discoveries have been made in the field. The first section of this review is devoted to highlight the main research findings and fundamental changes in the exercise redox biology discipline. It includes: i) the first steps in free radical research, ii) the relation between exercise and oxidative damage, iii) the redox regulation of muscle fatigue, iv) the sources of free radicals during muscle contractions, and v) the role of reactive oxygen species as regulators of gene transcription and adaptations in skeletal muscle. In the second section of the manuscript, we review the available biomarkers for assessing health, performance, recovery during exercise training and overtraining in the sport population. Among the set of biomarkers that could be determined in exercise studies we deepen on the four categories of redox biomarkers: i) oxidants, ii) antioxidants, iii) oxidation products (markers of oxidative damage), and iv) measurements of the redox balance (markers of oxidative stress). The main drawbacks, strengths, weaknesses, and methodological considerations of every biomarker are also discussed.
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 2213-2317, 2213-2317
- Tipo:
- Article
- Páginas:
- 101956-101956
- PubMed:
- 33811000
Redox Biology ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 46
Documentos
Filiaciones
Keywords
- Antioxidants; Biomarkers; Exercise; Free radical; Oxidative stress
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Cita
Gomez MC,Carretero A,Millan F,Garcia E,Correas AG,Olaso G,Vina J. Redox-related biomarkers in physical exercise. Redox Biol. 2021. 42. p. 101956-101956. IF:10,787. (1).
Redox-related biomarkers in physical exercise. Gomez MC, Carretero A, Millan F, Garcia E, Correas AG, Olaso G, Vina J. Redox Biology. 2021 junio 01. 42101956-101956. DOI:10.1016/j.redox.2021.101956. PMID:33811000.
