The multimodal action of genistein in Alzheimer's and other age-related diseases.

Fecha de publicación: 01/04/2022 Fecha Ahead of Print: 26/03/2022

Autores de INCLIVA

Grupos y Plataformas de I+D+i

Grupo de Investigación en Envejecimiento Saludable

Leading Researcher

Consuelo Borras Blasco
Grupo de investigación en envejecimiento y ejercicio físico

Leading Researcher

Jose Viña Ribes

Abstract

Genistein is a phytoestrogen that, due to its structural similarity with estrogen, can both mimic and antagonize estrogen effects. Early analysis proved that at high concentrations, genistein inhibits breast cancer cell proliferation, thereby suggesting an anticancer activity. Since then, many discoveries have identified the genistein mechanism of action, including cell cycle arrest, apoptosis induction, as well as angiogenesis, and metastasis inhibition. In this review, we aim to discuss the multimodal action of genistein as an antioxidant, anti-inflammatory, anti-amyloid ß, and autophagy promoter, which could be responsible for the genistein beneficial effect on Alzheimer's. Furthermore, we pinpoint the main signal transduction pathways that are known to be modulated by genistein. Genistein has thus several beneficial effects in several diseases, many of them associated with age, such as the above mentioned Alzheimer disease. Indeed, the beneficial effects of genistein for health promotion depend on each multimodality. In the context of geroscience, genistein has promising beneficial effects due to its multimodal action to treat age associated-diseases.

Datos de la publicación

ISSN/ISSNe:: 0891-5849, 1873-4596
Tipo:: Article
Páginas:: 127-137
DOI:: 10.1016/j.freeradbiomed.2022.03.021
PubMed:: 35346775

Documentos

Published Version

Métricas

Filiaciones

Mas-Bargues, Cristina:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain
Borras, Consuelo:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain
Vina, Jose:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigacion Biomedica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain