Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans.

Fecha de publicación: 23/08/2021 Fecha Ahead of Print: 23/08/2021

Autores de INCLIVA

Gloria Olaso Gonzalez

Autor
Juan Gambini Buchon

Autor

Participantes ajenos a INCLIVA

Stromsnes, Kristine
Lagzdina, Rudite
Gimeno-Mallench, Lucia

Grupos y Plataformas de I+D+i

Grupo de Investigación en Ejercicio, Nutrición y Estilo de Vida Saludable

Established Researcher

Maria Carmen Gomez Cabrera
Grupo de Investigación en Envejecimiento Saludable

Leading Researcher

Consuelo Borras Blasco

Abstract

Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

Datos de la publicación

ISSN/ISSNe:: 2227-9059, 2227-9059
Tipo:: Article
Páginas:: -
DOI:: 10.3390/biomedicines9081074
PubMed:: 34440278

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Filiaciones

Stromsnes, Kristine:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain
Lagzdina, Rudite:: Faculty of Medicine, Department of Human Physiology and Biochemistry, Riga Stradins University, LV-1007 Riga, Latvia
Olaso-Gonzalez, Gloria:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain
Gimeno-Mallench, Lucia:: Department of Biomedical Sciences, Faculty of Health Sciences, Cardenal Herrera CEU University, 46115 Valencia, Spain
Gambini, Juan:: CIBER. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, Faculty of Medicine, Institute of Health Research-INCLIVA, University of Valencia and CIBERFES, Avda. Blasco Ibañez, 15, 46010 Valencia, Spain