Redox modulation of muscle mass and function.

Autores de INCLIVA

• 

  Maria Carmen Gomez Cabrera

  Autor

• Coralie Arc-Chagnaud

  Autor

• Andrea Salvador Pascual

  Autor

• 

  Gloria Olaso Gonzalez

  Autor

• 

  Jose Viña Ribes

  Autor

Participantes ajenos a INCLIVA

• Brioche, T
• Chopard, A

Grupos y Plataformas de I+D+i

• Grupo de Investigación en Ejercicio, Nutrición y Estilo de Vida Saludable

  

  Established Researcher

  Maria Carmen Gomez Cabrera

• Grupo de investigación en envejecimiento y ejercicio físico

  

  Leading Researcher

  Jose Viña Ribes

Abstract

Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. Even short periods of disuse results in significant declines in muscle size, fiber cross sectional area, and strength. To understand the molecular signaling pathways involved in disuse muscle atrophy is of the utmost importance to develop more effective countermeasures in sport science research. We have divided our review in four different sections. In the first one we discuss the molecular mechanisms involved in muscle atrophy including the main protein synthesis and protein breakdown signaling pathways. In the second section of the review we deal with the main cellular, animal, and human atrophy models. The sources of reactive oxygen species in disuse muscle atrophy and the mechanism through which they regulate protein synthesis and proteolysis are reviewed in the third section of this review. The last section is devoted to the potential interventions to prevent muscle disuse atrophy with especial consideration to studies on which the levels of endogenous antioxidants enzymes or dietary antioxidants have been tested. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)