Portal de investigación
Extracellular vesicles and redox modulation in aging.
Autores de INCLIVA
Grupos y Plataformas de I+D+i
Abstract
Extracellular vesicles (EVs) are nowadays known to be mediators of cell-to-cell communication involved in physiological and pathological processes. The current expectation is their use as specific biomarkers and therapeutic tools due to their inner characteristics. However, several investigations still need to be done before we can use them in the clinic. First, their categorization is still under debate, although an accurate classification of EVs subtypes should be based on physical characteristics, biochemical composition or condition description of the cell of origin. Second, EVs carry lipids, proteins and nucleic acids that can induce epigenetic modifications on target cells. These cargos, as well as EVs biogenesis, shedding and uptake is both ageing and redox sensitive. More specifically, senescence and oxidative stress increase EVs release, and their altered content can trigger antioxidant but also prooxidant responses in target cells thereby modulating the redox status. Further analysis would help to asses EVs role in the development and progression of oxidative stress-related pathologies. In this review we aimed to summarize the current knowledge on EVs and their involvement in redox modulation on age-related pathologies. We also discuss future directions and prospective that could be performed to improve EVs usage as biomarkers or therapeutic tools. Copyright © 2019. Published by Elsevier Inc.
© 2019 Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0891-5849, 1873-4596
- Tipo:
- Review
- Páginas:
- 44-50
- PubMed:
- 31783096
FREE RADICAL BIOLOGY AND MEDICINE ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 33
Documentos
- No hay documentos
Filiaciones
Keywords
- Age-related disease; Extracellular vesicles; Treatment; Diagnosis
Financiación
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Cita
Borras C,Mas C,Sanz J,Roman A,Gimeno L,Ingles M,Gambini J,Vina J. Extracellular vesicles and redox modulation in aging. Free Radic. Biol. Med. 2020. 149p. 44-50. (1).
Extracellular vesicles and redox modulation in aging. Borras,Consuelo, Mas Bargues,Cristina, Sanz Ros,Jorge, Roman Dominguez,Aurora, Gimeno Mallench,Lucia, Ingles,Marta, Gambini,Juan et al. FREE RADICAL BIOLOGY AND MEDICINE. 2020 enero 01. 14944-50. DOI:10.1016/j.freeradbiomed.2019.11.032. PMID:31783096.
