Portal de investigación
Physical exercise in the prevention and treatment of Alzheimer's disease.
Fecha de publicación:
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Autores de INCLIVA
Grupos y Plataformas de I+D+i
Abstract
Dementia is one of the greatest global challenges for health and social care in the 21st century. Alzheimer's disease (AD), the most common type of dementia, is by no means an inevitable consequence of growing old. Several lifestyle factors may increase, or reduce, an individual's risk of developing AD. Much has been written overthe ages about the benefits of exercise and physical activity. Among the risk factors associated with AD is a low level of physical activity. The relationship between physical and mental health was established several years ago. In this review, we discuss the role of exercise (aerobic and resistance) training as a therapeutic strategy for the treatment and prevention of AD. Older adults who exercise are more likely to maintain cognition. We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies. We will pay especial attention to the potential role of exercise in the modulation of amyloid beta turnover, inflammation, synthesis and release of neurotrophins, and improvements in cerebral blood flow. Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide. Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. Copyright © 2020. Production and hosting by Elsevier B.V.
© 2020 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 2095-2546, 2095-2546
- Tipo:
- Article
- Páginas:
- 394-404
- PubMed:
- 32780691
Journal of Sport and Health Science Elsevier BV
Citas Recibidas en Web of Science: 346
Documentos
Filiaciones
Keywords
- Aerobic exercise; Dementia; Exercise training; Lifestyle factors; Multidomain interventions; Resistance exercise
Financiación
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Cita
De la Rosa A,Olaso G,Arc C,Millan F,Salvador A,Garcia C,Blasco C,Garcia E,Carretero A,Correas AG,Vina J,Gomez MC. Physical exercise in the prevention and treatment of Alzheimer's disease. J Sport Health Sci. 2020. 9. (5):p. 394-404. IF:7,179. (1).
Physical exercise in the prevention and treatment of Alzheimer's disease. De la Rosa A, Olaso G, Arc C, Millan F, Salvador A, Garcia C, Blasco C et al. Journal of Sport and Health Science. 2020 enero 01. 9 (5):394-404. DOI:10.1016/j.jshs.2020.01.004. PMID:32780691.
