Portal de investigación
Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- De la Rosa, A
- Solana, E
- Corpas, R
- Bartres-Faz, D
- Pallas, M
- Sanfeliu, C
Grupos y Plataformas de I+D+i
Abstract
Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exercise training (35 +/- 15 years) promotes memory maintenance in middle-aged men, and to characterize the changes in neurotrophic factors and lipid oxidation markers in peripheral blood samples in both middle-aged and young men. The neuropsychological analysis showed significant improvements in memory through the Free and Cued Immediate Recall tests, in the middle-aged trained individuals when compared to the sedentary ones. We found a significant decrease in the resting serum BDNF and plasma Cathepsin B (CTSB) levels in the trained groups at both middle and young ages. BDNF and CTSB levels were inversely correlated with weekly hours of exercise. We also found a significant decrease in plasma malondialdehyde, an index of lipid peroxidation, in middle-aged and young trained subjects. The positive impact of long-term exercise training by delaying the onset of physiological memory loss and the associated neurotrophic and redox peripheral modulation, suggests the effectiveness of exercise as preventive strategy against age-related memory loss and neurodegeneration.
© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Datos de la publicación
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipo:
- Article
- Páginas:
- 3337-3337
- PubMed:
- 30833610
Scientific Reports NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 93
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Cita
De la Rosa A,Solana E,Corpas R,Bartres D,Pallas M,Vina J,Sanfeliu C,Gomez MC. Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B. Sci Rep. 2019. 9. (1):p. 3337-3337. IF:3,998. (1).
Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B. De la Rosa A, Solana E, Corpas R, Bartres D, Pallas M, Vina J, Sanfeliu C et al. Scientific Reports. 2019 marzo 04. 9 (1):3337-3337. DOI:10.1038/s41598-019-40040-8. PMID:30833610.
