Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

Fecha de publicación: 01/03/2019 Fecha Ahead of Print: 08/03/2019

Autores de INCLIVA

Cristina Mas Bargues

Autor
Marta Inglés De La Torre

Autor
Lucia Gimeno Mallench

Autor
Jose Viña Almunia

Autor
Juan Gambini Buchon

Autor
Jose Viña Ribes

Autor
Consuelo Borras Blasco

Autor

Participantes ajenos a INCLIVA

Sanz-Ros, J
Roman-Dominguez, A
El Alami, M

Grupos y Plataformas de I+D+i

Grupo de investigación en envejecimiento y ejercicio físico

Leading Researcher

Jose Viña Ribes

Abstract

The key hallmark of stem cells is their ability to self-renew while keeping a differentiation potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell properties, and this is of the most importance when culturing them. One of these factors is oxygen concentration, which has been closely linked to the maintenance of stemness. The widely used environmental 21% O-2 concentration represents a hyperoxic non-physiological condition, which can impair stem cell behaviour by many mechanisms. The goal of this review is to understand these mechanisms underlying the oxygen signalling pathways and their negatively-associated consequences. This may provide a rationale for culturing stem cells under physiological oxygen concentration for stem cell therapy success, in the field of tissue engineering and regenerative medicine.

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Datos de la publicación

ISSN/ISSNe:: 1661-6596, 1422-0067
Tipo:: Review
Páginas:: 1195-1995
DOI:: 10.3390/ijms20051195
PubMed:: 30857245

Documentos

Published Version CC BY 4.0

Métricas

Filiaciones

Mas-Bargues, C:: CIBER. Freshage Research Group- Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibañez 15, CIBERFES, INCLIVA, 46010 Valencia, Spain.

Instituto de Investigación. Freshage Research Group- Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibañez 15, CIBERFES, INCLIVA, 46010 Valencia, Spain.
Ingles, M:: CIBER. Freshage Research Group- Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.

Instituto de Investigación. Freshage Research Group- Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.
Viña-Almunia J:: Master's Program in Oral Surgery and Implant Dentistry, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.