Redox lipidomics to better understand brain aging and function.

Fecha de publicación: 18/03/2019 Fecha Ahead of Print: 18/03/2019

Autores de INCLIVA

Consuelo Borras Blasco

Autor
Jose Viña Ribes

Autor

Participantes ajenos a INCLIVA

Pamplona R
Jové M
Pradas I
Ferrer I

Grupos y Plataformas de I+D+i

Grupo de investigación en envejecimiento y ejercicio físico

Leading Researcher

Jose Viña Ribes

Abstract

Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or deterioration of neurons and PFC functions are unknown. In this review, we focus on the role of lipids in human PFC aging. As the evolution of brain lipid concentrations is particularly accelerated in the human PFC, conferring a specific lipid profile, a brief approach to the lipidome of PFC was consider along with the relationship between lipids and lipoxidative damage, and the role of lipids in human PFC aging. In addition, the specific targets of lipoxidative damage in human PFC, the affected biological processes, and their potential role in the cognitive decline associated with aging are discussed. Finally, interventions designed to modify this process are considered. We propose that the dysfunction of key biological processes due to selective protein lipoxidation damage may have a role the cognitive decline of PFC during aging.

Datos de la publicación

ISSN/ISSNe:: 0891-5849, 1873-4596
Tipo:: Review
Páginas:: 310-321
DOI:: 10.1016/j.freeradbiomed.2019.03.016
PubMed:: 30898667

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Métricas

Filiaciones

Pamplona R:: Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain
Borras C:: CIBER. Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain

Instituto de Investigación. Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain
Jové M:: Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain
Pradas I:: Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain
Ferrer I:: Department of Pathology and Experimental Therapeutics, University of Barcelona, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain

Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), ISCIII, Spain
Viña J:: CIBER. Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain

Instituto de Investigación. Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain

Keywords

Advanced lipoxidation end products; Aging; Energy metabolism; Lipidomics; Mitochondrion; Neurotransmission; Oxidative stress; Prefrontal cortex; Proteostasis; Reactive carbonyl species