Portal de investigación
Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Borras-Barrachina, Aroa
- Rios, Maria-Pilar
- Kosenko, Elena
- Felipo, Vicente
Grupos y Plataformas de I+D+i
Abstract
Minimal hepatic encephalopathy (MHE) is associated with mild cognitive impairment and frailty. This study aims to identify cognitive and motor differences in cirrhotic patients with and without MHE, and the correlations between motor signs and cognitive performance. Gait, balance, hand strength and motor speed performance were evaluated in 66 cirrhotic patients (38 without and 28 with MHE, according to the Psychometric Hepatic Encephalopathy Score (PHES). Cognitive performance was measured with the Mini-Mental State Examination, Verbal Fluency Test, Aprendizaje Verbal Espana-Complutense Test (TAVEC), Wechsler Adult Intelligence Scale III, Hamilton Depression and Anxiety Rating Scale and Functioning Assessment Short Test (FAST). MHE patients performed worse than patients without MHE in cognitive and autonomous functioning, learning and long-term memory, and verbal fluency. The same pattern was found in gait, center of pressure movement, variability of hand strength performance and hand motor speed. In MHE patients, high correlations were found between balance and FAST test, gait velocity and verbal skills, hand strength variability and anxiety and depression, and motor speed and FAST and TAVEC. MHE patients showed worse motor and cognitive performance than patients without MHE. MHE patients could have impaired movement control expressed as bradykinesia, and this reduced motor performance could correlate with cognitive performance.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm9072154
- PubMed:
- 32650464
- Enlace a otro recurso:
- roderic.uv.es
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 26
Documentos
Filiaciones
Keywords
- biomechanics measurements, cognitive assessment, minimal hepatic encephalopathy
Financiación
Proyectos y Estudios Clínicos
Caracterización de las alteraciones neurológicas y cerebrales en pacientes con encefalopatía hepática mínima. Contribucu¡ión de la Inflamación. Implicaciones diagnósticas y terapéuticas
Investigador Principal: MARÍA DEL CARMEN MONTOLIU FÉLIX
PI18/00150 . INSTITUTO SALUD CARLOS III . 2019
Cita
San Martin C,Borras A,Gallego J,Urios A,Mestre V,Correa P,Ballester M,Escudero D,Tosca J,Monton C,Rios M,Kosenko E,Felipo V,Tabares R,Selva G,Montoliu C. Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy. J. Clin. Med. 2020. 9. (7):2154. IF:4,241. (1).
Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy. San Martin C, Borras A, Gallego J, Urios A, Mestre V, Correa P, Ballester M et al. Journal of Clinical Medicine. 2020 julio 08. 9 (7):DOI:10.3390/jcm9072154. PMID:32650464.
