Portal de investigación
Grupo de Investigación de Deterioro Neurológico
Responsable de la Unidad de Investigación:
Presentación de la unidad de investigación
Chronic liver disease progresses in different phases, including alcoholic or nonalcoholic liver disease and metabolic dysfunction-associated steatohepatitis (MASH) that can lead to fibrosis and cirrhosis. The incidence of MASH has increased considerably in recent decades due to the lifestyle of the western population and is beginning to be a leading cause of liver cirrhosis. It is etiologically related mainly to obesity, diabetes, hyperlipidemia, and insulin resistance with features of the metabolic syndrome. About 40% of patients with cirrhosis have minimal hepatic encephalopathy (MHE), with mild cognitive impairment and motor disorders that reduce their quality of life and survival. MHE progresses to clinical HE and can lead to coma and death. Early detection and treatment and prevention of cognitive and functional impairment would improve the quality of life, survival and vitality of patients with chronic liver diseases and would reduce hospitalizations and the demand for resources on the health system, improving its sustainability. In patients with liver cirrhosis, high levels of ammonia in the blood together with high levels of peripheral inflammation act synergistically to produce MHE, inducing neuroinflammation, which alters neurotransmission, leading to cognitive and motor impairment. A better characterization of the metabolic, immunological, cerebral and neurological alterations will make it possible to identify and evaluate new, earlier and more sensitive diagnostic procedures for MHE. The mechanisms that lead to these alterations are not well known and there are no specific treatments to reverse them. A better study of the mechanisms involved will make it possible to design and test new, more effective treatments. Our research aims to better characterize the alterations in MHE and the mechanisms that produce them, evaluating new diagnostic and therapeutic procedures. The aims of our study are: • Understand the biology of immunological changes associated with the appearance of MHE in cirrhotic patients • To advance in the knowledge of the molecular mechanisms that lead to neurological alterations in MHE • Identify new therapeutic targets • Improve the treatment of cognitive and functional impairment in cirrhotic patients with MHE and symptoms • Improve the early diagnosis of MHE, which will allow the treatment of patients who are not currently treated
Métricas
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Campos de Estudio
Colaboraciones internacionales
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