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Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation.

Fecha de publicación: Fecha Ahead of Print:

Autores de INCLIVA

Participantes ajenos a INCLIVA

  • Beltran-Garcia, Jesus

Grupos y Plataformas de I+D+i

Abstract

NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil "explosion" and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins. During sepsis, an exacerbated immune host response to an infection occurs, activating the innate immunity and NETosis events, which requires histone H3 citrullination. Our group compared the circulating histone levels with those citrullinated H3 levels in plasma samples of septic patients. In addition, we demonstrated that citrullinated histones were less cytotoxic for endothelial cells than histones without this post-translational modification. Citrullinated histones did not affect cell viability and did not activate oxidative stress. Nevertheless, citrullinated histones induced an inflammatory response, as well as regulatory endothelial mechanisms. Furthermore, septic patients showed elevated levels of circulating citrullinated histone H3, indicating that the histone citrullination is produced during the first stages of sepsis, probably due to the NETosis process.

Datos de la publicación

ISSN/ISSNe:
2073-4409, 2073-4409

Cells  MDPI

Tipo:
Article
Páginas:
-
PubMed:
36552833

Citas Recibidas en Web of Science: 13

Documentos

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Keywords

  • NETosis; biomarker; citrullination; histones; progression; sepsis; septic shock

Campos de Estudio

Financiación

AES2016 (PI16/01036)
European Regional Development Fund
European Social Fund
Generalitat Valenciana (CIAICO 2021/211)
Generalitat Valenciana (CIAPOT/2021/15)
GVA (GV/2014/132)
INCLIVA (GV/2014/132)
INSTITUTO SALUD CARLOS III (FI18/00323)
INSTITUTO SALUD CARLOS III (FI20/00202)
INSTITUTO SALUD CARLOS III (PI19/01714)

Proyectos y Estudios Clínicos

Determinación del perfil de expresión de miRNA en pacientes con infarto agudo de miocardio y estudio de la repercusión sobre su evolución clínica y sobre la función cardiaca y endotelial en modelos animales y celulares.

Investigador/a Principal ANA BELÉN PAES MARTÍ

FI18/00323 . INSTITUTO SALUD CARLOS III . 2019

Sex- and estrogen-dependent regulation of miRNA in Acute Coronary Syndrome and functional impact on human endothelial cells. New biomarkers for primary prevention.

Investigador/a Principal CARLOS HERMENEGILDO CAUDEVILLA

PI19/01714 . INSTITUTO SALUD CARLOS III . 2020

FI20/00202 DRA. REBECA OSCA VERDEGAL (2023/085)

Investigador/a Principal REBECA OSCA VERDEGAL

FI20/00202 . INSTITUTO SALUD CARLOS III . 2023

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