Portal de investigación
Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Delgado-Velandia, M
- Domingo-Relloso, A
- Galvez-Fernandez, M
- Olmedo, P
- Galan, I
- Rodriguez-Artalejo, F
- Amigo, N
- Briongos-Figuero, L
- Martin-Escudero, JC
- Tellez-Plaza, M
- Sotos-Prieto, M
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes. METHODS: A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001-2003, and were followed-up to 2015 to ascertain incident type 2 diabetes. RESULTS: The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and - 8.23 (95% CI, - 16.34, - 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes. CONCLUSIONS: The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis.
© 2022. The Author(s).
Datos de la publicación
- ISSN/ISSNe:
- 1479-5868, 1479-5868
- Tipo:
- Article
- Páginas:
- 8-8
- PubMed:
- 35086546
International Journal of Behavioral Nutrition and Physical Activity BioMed Central
Citas Recibidas en Web of Science: 26
Documentos
Filiaciones
Keywords
- Cohort study; Healthy lifestyle; Metabolomics; Spanish population; Type 2 diabetes
Financiación
Proyectos y Estudios Clínicos
Identificación de variantes genéticas en el exoma asociadas con DM2
Investigador Principal: FELIPE JAVIER CHAVES MARTÍNEZ
PI11/00726 . INSTITUTO SALUD CARLOS III . 2012
Cita
Delgado M,Gonzalez V,Domingo A,Galvez M,Grau M,Olmedo P,Galan I,Rodriguez F,Amigo N,Briongos L,Redon J,Martin JC,Monleon D,Tellez M,Sotos M. Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain. Int. J. Behav. Nutr. Phys. Act. 2022. 19. (1):p. 8-8. IF:8,700. (1).
Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain. Delgado M, Gonzalez V, Domingo A, Galvez M, Grau M, Olmedo P, Galan I et al. International Journal of Behavioral Nutrition and Physical Activity. 2022 enero 27. 19 (1):8-8. DOI:10.1186/s12966-021-01219-3. PMID:35086546.
