Portal de investigación
Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Gimenez-Garzo, Carla
- Aparicio, Luis
- Rios, Maria-Pilar
- Durban, Lucia
- Mir, Amparo
- Kosenko, Elena
- Felipo, Vicente
Grupos y Plataformas de I+D+i
Abstract
Cirrhotic patients may experience alterations in the peripheral nervous system and in somatosensory perception. Impairment of the somatosensory system could contribute to cognitive and motor alterations characteristic of minimal hepatic encephalopathy (MHE), which affects up to 40% of cirrhotic patients. We assessed the relationship between MHE and alterations in thermal, vibration, and/or heat pain sensitivity in 58 cirrhotic patients (38 without and 20 with MHE according to Psychometric Hepatic Encephalopathy Score) and 39 controls. All participants underwent attention and coordination tests, a nerve conduction study, autonomic function testing, and evaluation of sensory thresholds (vibration, cooling, and heat pain detection) by electromyography and quantitative sensory testing. The detection thresholds for cold and heat pain on the foot were higher in patients with, than those without MHE. This hyposensitivity was correlated with attention deficits. Reaction times in the foot were longer in patients with, than without MHE. Patients with normal sural nerve amplitude showed altered thermal sensitivity and autonomic function, with stronger alterations in patients with, than in those without MHE. MHE patients show a general decrease in cognitive and sensory abilities. Small fibers of the autonomic nervous system and thermal sensitivity are altered early on in MHE, before large sensory fibers. Quantitative sensory testing could be used as a marker of MHE.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- 239-239
- DOI:
- 10.3390/jcm10020239
- PubMed:
- 33440769
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 7
Documentos
Filiaciones
Keywords
- autonomic testing; minimal hepatic encephalopathy; nerve conduction; thermal sensitivity
Financiación
Proyectos y Estudios Clínicos
Caracterización de las alteraciones neurológicas en pacientes con encefalopatía hepática mínima. Estudio de mecanismos implicados.
Investigador Principal: JUAN JOSÉ GALLEGO ROIG
ACIF/2018/284 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2018
Caracterización de las alteraciones neurológicas y cerebrales en pacientes con encefalopatía hepática mínima. Contribucu¡ión de la Inflamación. Implicaciones diagnósticas y terapéuticas
Investigador Principal: MARÍA DEL CARMEN MONTOLIU FÉLIX
PI18/00150 . INSTITUTO SALUD CARLOS III . 2019
Caracterización de las alteraciones neurológicas y cerebrales en pacientes con encefalopatía hepática mínima. contribución de la inflamación. Implicaciones diagnósticas y terapéuticas.
Investigador Principal: MARÍA DEL CARMEN MONTOLIU FÉLIX
GRISOLIAP/2019/003 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2019
ESTUDIO DE LAS ALTERACIONES NEUROLÓGICAS, CEREBRALES Y BIOQUÍMICAS EN PACIENTES CON ENFERMEDAD GRASA DEL HÍGADO. MECANISMOS MOLECULARES Y CELULARES.
Investigador Principal: FRANC CASANOVA FERRER
ACIF/2019/232 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO
CONTRATOS RIO HORTEGA 2019
Investigador Principal: MARIA PILAR BALLESTER FERRE
CM19/00011 . INSTITUTO SALUD CARLOS III . 2020
Cita
Rega D,Aiko M,Penaranda N,Urios A,Gallego J,Gimenez C,Casanova F,Fiorillo A,Cabrera A,San T,Ipiens C,Escudero D,Tosca J,Monton C,Ballester M,Ballester J,Aparicio L,Rios M,Durban L,Mir A,Kosenko E,Cases P,Felipo V,Montoliu C. Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function. J. Clin. Med. 2021. 10. (2):p. 239-239. IF:4,964. (2).
Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function. Rega D, Aiko M, Penaranda N, Urios A, Gallego J, Gimenez C, Casanova F et al. Journal of Clinical Medicine. 2021 enero 11. 10 (2):239-239. DOI:10.3390/jcm10020239. PMID:33440769.
