Methionine transsulfuration pathway is upregulated in long-lived humans.

Fecha de publicación: 30/11/2020 Fecha Ahead of Print: 30/11/2020

Autores de INCLIVA

Consuelo Borras Blasco

Autor
Jose Viña Ribes

Autor

Participantes ajenos a INCLIVA

Mota-Martorell, Natalia
Mariona, Jove
Rebeca, Berdun
Elia, Obis
Joaquim, Sol
Rosanna, Cabre
Irene, Pradas
Galo-Licona, Jose Daniel
Josep, Puig
Reinald, Pamplona

Grupos y Plataformas de I+D+i

Grupo de Investigación en Envejecimiento Saludable

Leading Researcher

Consuelo Borras Blasco
Grupo de investigación en envejecimiento y ejercicio físico

Leading Researcher

Jose Viña Ribes

Abstract

Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically define specific phenotypic patterns associated with genotypes of human extreme longevity (centenarians). Our findings demonstrate the presence of a specific plasma profile associated with human longevity characterized by an enhanced transsulfuration pathway and tricarboxylic acid (TCA) cycle intermediates, as well as a reduced content of specific amino acids. Furthermore, our work reveals that centenarians maintain a strongly correlated methionine metabolism, suggesting an improved network integrity, homeostasis and more tightly regulated metabolism. We have discovered a particular methionine signature related to the condition of extreme longevity, allowing the identification of potential mechanisms and biomarkers of healthy aging.

Datos de la publicación

ISSN/ISSNe:: 0891-5849, 1873-4596
Tipo:: Article
Páginas:: 38-52
DOI:: 10.1016/j.freeradbiomed.2020.11.026
PubMed:: 33271279

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Métricas

Filiaciones

Mota-Martorell, Natalia:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Mariona, Jove:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Consuelo, Borras:: CIBER. Freshage Research Group, Department of Physiology, University of Valencia, CIBERFES, INCLIVA, Valencia, Spain

Instituto de Investigación. Freshage Research Group, Department of Physiology, University of Valencia, CIBERFES, INCLIVA, Valencia, Spain
Rebeca, Berdun:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Elia, Obis:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Joaquim, Sol:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Rosanna, Cabre:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Irene, Pradas:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Galo-Licona, Jose Daniel:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Josep, Puig:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain
Reinald, Pamplona:: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida, Catalonia, Spain