Portal de investigación
Relation of Low Lymphocyte Count to Frailty and its 11) Usefulness as a Prognostic Biomarker in Patients >65 Years of Age With Acute Coronary Syndrome
Autores de INCLIVA
Participantes ajenos a INCLIVA
- D'Ascoli, G
- Ruescas-Nicolau, MA
- Nunez, E
- Formiga, F
Grupos y Plataformas de I+D+i
Abstract
Low lymphocyte count, as a marker of inflammation and immunosuppression, may be use-ful for identifying frail patients. In this work, we aimed to evaluate the association between low-relative lymphocyte count (Lymph%) and frailty status in patients >65 years old with acute coronary syndromes (ACS), and whether Lymph % is associated with morbimortality beyond standard prognosticators and frailty. In this prospective observational study, we included 488 hospital survivors of an episode of an ACS >65 years old. Total and differential white blood cells and frailty status were assessed at discharge. Frailty was evaluated using the Fried score at discharge and defined as Fried >= 3. The independent association between Lymph% and Fried >= 3 was evaluated by multivariate logistic regression analysis. The associations between Lymph% with long-term all-cause mortality and recurrent admission were evaluated with Cox regression and shared frailty regression, respectively. The mean age of the sample was 78 +/- 7 years and 41% were females. The median (interquartile range) of the Lymph% was 21% (15 to 27) and 41% showed Fried >= 3. In multivariate analysis, Lymph% was inversely related to the odds of frailty with an exponential increase risk from values below 15% (p = 0.001). Likewise, Lymph% was inverse and independently associated with a higher risk of long-term mortality (p = 0.011), recurrent all-cause (p = 0.020), and cardiovascular readmissions (p = 0.024). In conclusion, in patients >65 years with a recent ACS, low Lymph% evaluated at discharge is associated with a higher risk of frailty. Low Lymph% was also associated with a higher risk of long-term mortality and recurrent admissions beyond standard prognosticators and Fried score. (C) 2020 Elsevier Inc. All rights reserved.
© 2020 Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0002-9149, 1879-1913
- Tipo:
- Article
- Páginas:
- 1033-1038
- PubMed:
- 31959430
AMERICAN JOURNAL OF CARDIOLOGY EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 23
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Filiaciones
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Nunez J,Sastre C,D'Ascoli G,Ruiz V,Bonanad C,Minana G,Valero E,Garcia S,Mollar A,Villaescusa A,Ruescas MA,Nunez E,Formiga F,Chorro FJ,Sanchis J. Relation of Low Lymphocyte Count to Frailty and its 11) Usefulness as a Prognostic Biomarker in Patients >65 Years of Age With Acute Coronary Syndrome. Am J Cardiol. 2020. 125. (7):p. 1033-1038. IF:2,778. (3).
Relation of Low Lymphocyte Count to Frailty and its 11) Usefulness as a Prognostic Biomarker in Patients >65 Years of Age With Acute Coronary Syndrome. Nunez J, Sastre C, D'Ascoli G, Ruiz V, Bonanad C, Minana G, Valero E et al. AMERICAN JOURNAL OF CARDIOLOGY. 2020 abril 01. 125 (7):1033-1038. DOI:10.1016/j.amjcard.2020.01.006. PMID:31959430.
