Portal de investigación
Lipoprotein(a) and long-term recurrent infarction after an episode of ST-segment elevation acute myocardial infarction.
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Gil-Cayuela, Carolina
- Marco, Maria
- Garcia-Ballester, Teresa
- Zorio, Begona
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: In established ischemic heart disease, the relationship between lipoprotein(a) and new cardiovascular events showed contradictory results. Our aim was to assess the relationship between lipoprotein(a) and very long-term recurrent myocardial infarction (MI) after an index episode of ST-segment elevation acute myocardial infarction (STEMI).; METHODS: We included 435 consecutive STEMI patients discharged from October 2000 to June 2003 in a single teaching center. The relationship between lipoprotein(a) at discharge and recurrent MI was evaluated through negative binomial regression and Cox regression analysis.; RESULTS: The mean age was 65years (55-74years), 25.5% were women, 34.7% were diabetic, and 66% had a MI of anterior location. Fibrinolysis, rescue, or primary angioplasty was performed in 215 (49.4%), 19 (4.4%), and 18 (4.1%) patients, respectively. The median lipoprotein(a) was 30.4mg/dL (12-59.4mg/dL). After a median follow-up of 9.6years (4.1-15years), 180 (41.4%) deaths and 187 MI in 133 (30.6%) patients were recorded. After a multivariate adjustment, the risk gradient of lipoprotein(a) showed a neutral effect along most of the continuum and only extreme higher values identified those at higher risk of recurrent MI (P=0.020). Those with lipoprotein(a) values >95th percentile (=135mg/dL) showed a higher risk of recurrent MI (incidence rate ratio, 2.34; 95% confidence interval, 1.37-4.02; P=0.002). Lipoprotein(a) was not related to the risk of mortality (P=0.245).; CONCLUSIONS: After an episode of STEMI, only extreme high values of lipoprotein(a) were associated with an increased risk of long-term recurrent MI.
© 2020 Wolters Kluwer Health, Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0954-6928, 1473-5830
- Tipo:
- Article
- Páginas:
- 378-384
- PubMed:
- 32040026
Coronary Artery Disease Lippincott Williams & Wilkins Ltd.
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- lipoprotein(a); prognosis; ST-segment elevation acute myocardial infarction; reinfarction
Financiación
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo de miocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b (PI17/01836).
Investigador Principal: VICENT BODÍ PERIS
PI17/01836 . INSTITUTO SALUD CARLOS III . 2018
Cita
Minana G,Gil C,Bodi V,de la Espriella R,Valero E,Mollar A,Marco M,Garcia T,Zorio B,Fernandez A,Chorro FJ,Sanchis J,Nunez J. Lipoprotein(a) and long-term recurrent infarction after an episode of ST-segment elevation acute myocardial infarction. Coronary Artery Dis. 2020. 31. (4):p. 378-384. IF:1,439. (4).
Lipoprotein(a) and long-term recurrent infarction after an episode of ST-segment elevation acute myocardial infarction. Minana G, Gil C, Bodi V, de la Espriella R, Valero E, Mollar A, Marco M et al. Coronary Artery Disease. 2020 junio 01. 31 (4):378-384. DOI:10.1097/MCA.0000000000000852. PMID:32040026.
