LAM study: Effects of lacosamide on behaviour and quality of life in patients with epilepsy

Fecha de publicación: 01/01/2019

Autores de INCLIVA

Jose Maria Salom Juan

Autor

Participantes ajenos a INCLIVA

Alfaro, A
Asensio, M
Garcia-Escriva, A
Medrano, V
Tortosa, D
Palao, S
Lezcano, M
Berenguer, L
Navarro, M
Cerdan, M
Buendia, JF
Giner, JC

Abstract

Introduction: Psychiatric comorbidities are common in epileptic patients, and evaluating the impact of antiepileptic drugs on patients' moods is therefore essential. The aim of this study is to assess the effects of lacosamide on behaviour and quality of life in people with epilepsy. Methods: We conducted a multicentre prospective observational study of poorly-controlled epileptic patients who received lacosamide as an adjuvant treatment. Patients were evaluated on 4 occasions during a 12-month period. The impact of lacosamide on patients' mood and quality of life was assessed with the Quality of Life in Epilepsy Inventory-10 (QOLIE-10), the Hospital Anxiety and Depression Scale (HADS), and the Barratt Impulsiveness Scale (BIS-11). As a secondary objective, we evaluated the effectiveness and safety of lacosamide. Results: We included 55 patients with a mean age of 47.1 +/- 18.4 years. At baseline, 34.5% of the patients had psychiatric comorbidities; the mean number of crises in the previous month was 3.6 +/- 4.3. The QOLIE-10 and HADS scales revealed statistically significant improvements in patients with a poor baseline condition (anxiety, depression, and/or poor quality of life). The BIS-11 scale detected no impulsive behaviour during follow-up. After 12 months of treatment, 51.9% of the patients were seizure-free and 77.8% experienced a reduction of at least 50% in seizure frequency. Adverse effects were mild in most cases; lacosamide was discontinued in 10 patients (18.2%). Conclusions: Lacosamide is a safe and effective treatment option for patients with epilepsy and psychiatric comorbidities. (C) 2016 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U.

Datos de la publicación

ISSN/ISSNe:: 0213-4853, 1578-1968
Tipo:: Article
Páginas:: 1-6
DOI:: 10.1016/j.nrl.2016.10.007
PubMed:: 27993420

Documentos

Published Version

Métricas

Filiaciones

Keywords

Epilepsy; Lacosamide; Quality of life; Depression; Anxiety; Impulsiveness

Campos de Estudio

Financiación

INSTITUTO SALUD CARLOS III (PI15/00082)

Proyectos y Estudios Clínicos

Estudio de nuevos mecanismos inflamatorios y angiogénicos asociados a la obesidad grave morbida: papel del eje CXCR3 y los receptores RORs.

Investigador Principal: LAURA PIQUERAS RUIZ

PI15/00082 . INSTITUTO SALUD CARLOS III . 2016