Portal de investigación
Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Palau, Patricia
- Bertomeu-Gonzalez, Vicente
- Dominguez, Eloy
- Nunez, Eduardo
- Bayes-Genis, Antoni
Grupos y Plataformas de I+D+i
Abstract
Introduction and objectives: Type 2 diabetes mellitus (DM2) is a common comorbidity in patients with heart failure (HF) with preserved ejection fraction (HFpEF). Previous studies have shown that diabetic women are at higher risk of developing HF than men. However, the long-term prognosis of diabetic HFpEF patients by sex has not been extensively explored. In this study, we aimed to evaluate the differential impact of DM2 on all-cause mortality in men vs women with HFpEF after admission for acute HF. Methods: We prospectively included 1019 consecutive HFpEF patients discharged after admission for acute HF in a single tertiary referral hospital. Multivariate Cox regression analysis was used to evaluate the interaction between sex and DM2 regarding the risk of long-term all-cause mortality. Risk estimates were calculated as hazard ratios (HR). Results: The mean age of the cohort was 75.6 +/- 9.5 years and 609 (59.8%) were women. The proportion of DM2 was similar between sexes (45.1% vs 49.1%, P = .211). At a median (interquartile range) follow-up of 3.6 (1-4-6.8) years, 646 (63.4%) patients died. After adjustment for risk factors, comorbidities, biomarkers, echo parameters and treatment at discharge, multivariate analysis showed a differential prognostic effect of DM2 (P value for interaction = .007). DM2 was associated with a higher risk of all-cause mortality in women (HR, 1.77; 95%CI, 1.41-2.21; P < .001) but not in men (HR, 1.23; 95%CI, 0.94-1.61; P = .127). Conclusions: After an episode of acute HF in HFpEF patients, DM2 confers a higher risk of mortality in women. Further studies evaluating the impact of DM2 in women with HFpEF are warranted. (C) 2019 Sociedad Espanola de Cardiologi ' a. Published by Elsevier Espana, S.L.U. All rights reserved.
© 2019 Sociedad Espan˜ola de Cardiologi´a. Publicado por Elsevier Espan˜a, S.L.U. Todos los derechos reservados.
Datos de la publicación
- ISSN/ISSNe:
- 1885-5857, 1579-2242
- Tipo:
- Article
- Páginas:
- 463-470
- PubMed:
- 31629690
REVISTA ESPANOLA DE CARDIOLOGIA Elsevier Doyma
Citas Recibidas en Web of Science: 12
Documentos
Filiaciones
Keywords
- Heart failure with preserved ejection fraction; Sex differences; Women; Diabetes mellitus; Mortality
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Palau P,Bertomeu V,Sanchis J,Soler M,de la Espriella R,Dominguez E,Santas E,Nunez E,Chorro FJ,Minana G,Bayes A,Nunez J. Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction. Rev. Esp. Cardiol. 2020. 73. (6):p. 463-470. IF:4,753. (2).
Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction. Palau P, Bertomeu V, Sanchis J, Soler M, de la Espriella R, Dominguez E, Santas E et al. REVISTA ESPANOLA DE CARDIOLOGIA. 2020 junio 01. 73 (6):463-470. DOI:10.1016/j.rec.2019.09.002. PMID:31629690.
