Portal de investigación
Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Vila-Caballer, Marian
- Gonzalez-Granado, Jose M
- Zorita, Virginia
- Abu Nabah, Yafa N
- Silvestre-Roig, Carlos
- Del Monte-Monge, Alberto
- Molina-Sanchez, Pedro
- Ait-Oufella, Hafid
- Andres-Manzano, Maria J
- Weber, Christian
- Kremer, Leonor
- Gutierrez, Julio
- Mallat, Ziad
- Andres, Vicente
Grupos y Plataformas de I+D+i
Abstract
The CC chemokine 1 (CCL1, also called I-309 or TCA3) is a potent chemoattractant for leukocytes that plays an important role in inflammatory processes and diseases through binding to its receptor CCR8. Here, we investigated the role of the CCL1-CCR8 axis in atherosclerosis. We found increased expression of CCL1 in the aortas of atherosclerosis-prone fat-fed apolipoprotein E (Apoe)-null mice; moreover, in vitro flow chamber assays and in vivo intravital microscopy demonstrated an essential role for CCL1 in leukocyte recruitment. Mice doubly deficient for CCL1 and Apoe exhibited enhanced atherosclerosis in aorta, which was associated with reduced plasma levels of the anti-inflammatory interleukin 10, an increased splenocyte Th1/Th2 ratio, and a reduced regulatory T cell (Treg) content in aorta and spleen. Reduced Treg recruitment and aggravated atherosclerosis were also detected in the aortas of fat-fed low-density lipoprotein receptor-null mice treated with CCR8 blocking antibodies. These findings demonstrate that disruption of the CCL1-CCR8 axis promotes atherosclerosis by inhibiting interleukin 10 production and Treg recruitment and function.
© 2019 Elsevier Ltd. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0022-2828, 1095-8584
- Tipo:
- Article
- Páginas:
- 154-163
- PubMed:
- 31121182
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citas Recibidas en Web of Science: 38
Documentos
- No hay documentos
Filiaciones
Keywords
- Atherosclerosis; CCL1; CCR8; Treg; IL-10
Proyectos y Estudios Clínicos
Modulación inmunofarmacológica de la inflamación sistémica asociada a desórdenes metabólicos. Búsqueda de nuevas dianas terapéuticas y síntesis de fármacos novedosos.
Investigador Principal: MARIA JESUS SANZ FERRANDO
SAF2014-57845-R . MINISTERIO ECONOMIA Y COMPETITIVIDAD . 2015
Cita
Vila M,Gonzalez JM,Zorita V,Abu YN,Silvestre C,Del Monte A,Molina P,Ait H,Andres MJ,Sanz MJ,Weber C,Kremer L,Gutierrez J,Mallat Z,Andres V. Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. J Mol Cell Cardiol. 2019. 132. p. 154-163. IF:4,133. (2).
Disruption of the CCL1-CCR8 axis inhibits vascular Treg recruitment and function and promotes atherosclerosis in mice. Vila M, Gonzalez JM, Zorita V, Abu YN, Silvestre C, Del Monte A, Molina P et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2019 enero 01. 132154-163. DOI:10.1016/j.yjmcc.2019.05.009. PMID:31121182.
