Portal de investigación
Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Garrido-Martinez MJ
- Navas-Acien A
- Gomez-Ariza JL
- Garcia-Barrera T
- Dueñas Laita A
- Briongos Figuero LS
- Martin-Escudero JC
Grupos y Plataformas de I+D+i
Abstract
Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine(8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 0160-4120, 1873-6750
- Tipo:
- Article
- Páginas:
- 171-180
- PubMed:
- 30529889
- Enlace a otro recurso:
- roderic.uv.es
ENVIRONMENT INTERNATIONAL PERGAMON-ELSEVIER SCIENCE LTD
Citas Recibidas en Web of Science: 85
Documentos
Filiaciones
Keywords
- Urine metals; Oxidative stress; Metal mixtures; Population-based
Financiación
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Cita
Domingo A,Grau M,Galan I,Garrido MJ,Tormos C,Navas A,Gomez JL,Monzo L,Saez G,Garcia T,Dueñas A,Briongos LS,Martin JC,Chaves FJ,Redon J,Tellez M. Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study. Environ Int. 2019. 123. p. 171-180. IF:7,577. (1).
Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study. Domingo A, Grau M, Galan I, Garrido MJ, Tormos C, Navas A, Gomez JL et al. ENVIRONMENT INTERNATIONAL. 2019 febrero 01. 123171-180. DOI:10.1016/j.envint.2018.11.055. PMID:30529889.
