Portal de investigación
Circulating histones as clinical biomarkers in critically ill conditions
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Ruiz-Rodríguez, JC
- Ferrer, R
- Durá, R
- Artigas, A
- Bajaña, I
- Ceccato, A
- Chiscano-Camón, L
- Goma, G
- Monforte, V
- Ruiz-Sanmartín, A
- Sierra-Rivera, A
Grupos y Plataformas de I+D+i
Abstract
Extracellular histones, primarily nuclear proteins involved in chromatin organization, have emerged as key mediators in pathological processes in critically ill patients. When released into circulation due to cell death mechanisms such as NETosis, histones act as damage-associated molecular patterns (DAMPs), contributing to excessive inflammation, endothelial dysfunction, immune response dysregulation, coagulation activation, cell death, and multi-organ damage. Increasing evidence supports their role in the pathophysiology of sepsis, acute lung injury, cardiac injury, pancreatitis, and other life-threatening conditions. Given their strong association with disease severity and prognosis, circulating histones have gained attention as potential clinical biomarkers for early diagnosis, prognosis, and therapeutic monitoring in critically ill patients. This review discusses the biological roles of extracellular histones, their potential as biomarkers, different approaches to measure them, and emerging therapeutic strategies aimed at neutralizing or removing circulating histones to improve patient outcomes in severe medical conditions. Impact statement This review highlights extracellular histones as key mediators and biomarkers in sepsis, proposing their use in diagnosis, prognosis, and treatment monitoring. Integrating quantitative proteomics for the detection of circulating histones may enhance patient stratification and guide therapeutic strategies, advancing personalized medicine in critical care.
© 2025 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Datos de la publicación
- ISSN/ISSNe:
- 0014-5793, 1873-3468
- Tipo:
- Review
- Páginas:
- 3174-3195
- PubMed:
- 40527588
FEBS LETTERS WILEY
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- acute kidney injury; cardiac injury; COVID-19; critically-ill patient; extracellular histones; lung injury; mass spectrometry; pancreatitis; renal replacement therapy; sepsis; septic shock
Financiación
Proyectos y Estudios Clínicos
Proteómica cuantitativa por espectrometría de masas para la identificación temprana de biomarcadores predictivos de eventos adversos en el síndrome coronario agudo.
Investigador/a Principal JOSE LUIS GARCIA GIMENEZ
DTS24/00094 . INSTITUTO SALUD CARLOS III . 2025
Cita
Circulating histones as clinical biomarkers in critically ill conditions. García Gimenez,JL, Ruiz Rodríguez,JC, Ferrer,R, Durá,R, Artigas,A, Bajaña,I, de Andujar,DBL et al. FEBS LETTERS. 2025 junio 17. 599 (22):3174-3195. DOI:10.1002/1873-3468.70093. PMID:40527588.
