Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies

Fecha de publicación: 01/03/2025 Fecha Ahead of Print: 01/12/2024

Autores de INCLIVA

Susana Novella Del Campo

Autor

Participantes ajenos a INCLIVA

Kardassis D
Vindis C
Stancu CS
Toma L
Gafencu AV
Georgescu A
Alexandru-Moise N
Molica F
Kwak BR
Burlacu A
Hall IF
Butoi E
Magni P
Wu J
Gamon LF
Davies MJ
Caporali A
de la Cuesta F
Mitic T
EU-AtheroNET COST Action CA21153

Grupos y Plataformas de I+D+i

Grupo de Investigación en Células Endoteliales (LINCE)

Leading Researcher Co-IP

Susana Novella Del Campo

Abstract

Despite the discovery and prevalent clinical use of potent lipid-lowering therapies, including statins and PCSK9 inhibitors, cardiovascular diseases (CVD) caused by atherosclerosis remain a large unmet clinical need, accounting for frequent deaths worldwide. The pathogenesis of atherosclerosis is a complex process underlying the presence of modifiable and non-modifiable risk factors affecting several cell types including endothelial cells (ECs), monocytes/macrophages, smooth muscle cells (SMCs) and T cells. Heterogeneous composition of the plaque and its morphology could lead to rupture or erosion causing thrombosis, even a sudden death. To decipher this complexity, various cell model systems have been developed. With recent advances in systems biology approaches and single or multi-omics methods researchers can elucidate specific cell types, molecules and signalling pathways contributing to certain stages of disease progression. Compared with animals, in vitro models are economical, easily adjusted for high-throughput work, offering mechanistic insights. Hereby, we review the latest work performed employing the cellular models of atherosclerosis to generate a variety of omics data. We summarize their outputs and the impact they had in the field. Challenges in the translatability of the omics data obtained from the cell models will be discussed along with future perspectives.

Datos de la publicación

ISSN/ISSNe:: 1537-1891, 1879-3649
Tipo:: Article
Páginas:: 107452-107452
DOI:: 10.1016/j.vph.2024.107452
PubMed:: 39667548

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Filiaciones

Kardassis D:: University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion, Greece
Vindis C:: CARDIOMET, Center for Clinical Investigation 1436 (CIC1436)/INSERM, Toulouse, France
Stancu CS:: Lipidomics Department, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Toma L:: Lipidomics Department, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Gafencu AV:: Gene Regulation and Molecular Therapies Department, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Georgescu A:: Pathophysiology and Cellular Pharmacology Department, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Alexandru-Moise N:: Pathophysiology and Cellular Pharmacology Department, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Molica F:: Department of Pathology and Immunology, Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Kwak BR:: Department of Pathology and Immunology, Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Burlacu A:: Department of Stem Cell Biology, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Hall IF:: Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Butoi E:: Department of Biopathology and Therapy of Inflammation, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
Magni P:: Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milano, Italy

IRCCS Multimedica, Milan, Italy
Wu J:: University of Strathclyde, Glasgow, United Kingdom
Novella S:: Instituto de Investigación. Department of Physiology, University of Valencia - INCLIVA Biomedical Research Institute, Valencia, Spain
Gamon LF:: Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Davies MJ:: Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Caporali A:: Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
de la Cuesta F:: Department of Pharmacology and Therapeutics, School of Medicine, Universidad Autónoma de Madrid, Spain

Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain
Mitic T:: Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom