Portal de investigación
Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Llopis-Lorente, J
- Monmeneu, JV
- Lopez-Lereu, MP
- Bayés-Genis, A
Grupos y Plataformas de I+D+i
Abstract
We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was 31 ± 13 mL/m(2). Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at 6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field.
Datos de la publicación
- ISSN/ISSNe:
- 2075-4418, 2075-4418
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 38396407
Diagnostics MDPI AG
Citas Recibidas en Web of Science: 1
Documentos
- No hay documentos
Filiaciones
Keywords
- ST-segment elevation myocardial infarction; cardiovascular magnetic resonance; epicardial adipose tissue; infarct size; left ventricular ejection fraction
Financiación
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Cita
Gavara J,Merenciano H,Llopis J,Molina T,Perez N,de Dios E,Marcos V,Monmeneu JV,Lopez MP,Canoves J,Bonanad C,Moratal D,Nuñez J,Bayés A,Sanchis J,Chorro FJ,Rios C,Bodí V. Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction. Diagnostics. 2024. 14. (4):368. IF:3,300. (1).
Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction. Gavara J, Merenciano H, Llopis J, Molina T, Perez N, de Dios E, Marcos V et al. Diagnostics. 2024 febrero 07. 14 (4):DOI:10.3390/diagnostics14040368. PMID:38396407.
