Portal de investigación
Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Llopis-Lorente, J
- Monmeneu, JV
- Lopez-Lereu, MP
- Bayés-Genis, A
Grupos y Plataformas de I+D+i
Abstract
We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was 31 +/- 13 mL/m(2). Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at 6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field.
Datos de la publicación
- ISSN/ISSNe:
- 2075-4418, 2075-4418
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 38396407
Diagnostics MDPI AG
Citas Recibidas en Web of Science: 1
Documentos
Filiaciones
Keywords
- ST-segment elevation myocardial infarction; epicardial adipose tissue; cardiovascular magnetic resonance; infarct size; left ventricular ejection fraction
Financiación
Proyectos y Estudios Clínicos
Resolution of microvascular obstruction after myocardial infarction. A multidisciplinary approach to assess the structural and clinical consequences and to evaluate new therapeutic options.
Investigador Principal: VICENT BODÍ PERIS
PI20/00637 . INSTITUTO SALUD CARLOS III . 2021
A multidisciplinary study to advance in the understanding of the basic mechanisms and clinical implications of microvascular obstruction after acute myocardial infarction. Exploration of novel diagnostic and therapeutic opportunities.
Investigador Principal: VICENT BODÍ PERIS
PROMETEO/2021/008 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2021
MEDICINA DE PRECISIÓN MEDIANTE RESONANCIA MAGNÉTICA CARDÍACA EN PACIENTES TRAS INFARTO AGUDO DE MIOCARDIO CON ELEVACIÓN DEL SEGMENTO ST: UTILIDAD CLÍNICA EN SITUACIONES ESPECIALES.
Investigador Principal: VICTOR MARCOS GARCÉS
CIGE/2022/26 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2023
Obstrucción microvascular tras un infarto de miocardio. Avances hacia una cuantificación automatizada, biomarcadores basados en técnicas ómicas y una estratificación de riesgo a largo plazo personalizada.
Investigador Principal: VICENT BODÍ PERIS
PI23/01150 . INSTITUTO SALUD CARLOS III . 2024
Cita
Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction. Gavara J, Merenciano H, Llopis J, Molina T, Perez N, de Dios E, Marcos V et al. Diagnostics. 2024 febrero 01. 14 (4):DOI:10.3390/diagnostics14040368. PMID:38396407.
