Portal de investigación
The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation.
Fecha de publicación:
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Autores de INCLIVA
Participantes ajenos a INCLIVA
- Cánovas-Cervera I
- Dolz-Andrés E
- Beltrán-García J
Grupos y Plataformas de I+D+i
Abstract
Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K/AKT/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore.
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Datos de la publicación
- ISSN/ISSNe:
- 1661-6596, 1422-0067
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/ijms24032582
- PubMed:
- 36768905
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES MDPI
Citas Recibidas en Web of Science: 6
Documentos
Filiaciones
Keywords
- Disseminated Intravascular Coagulation; biomarkers; lncRNAs; miRNAs; non-coding RNAs; sepsis
Financiación
Proyectos y Estudios Clínicos
SEPSIS-HISTSHOCK: Valorización, estrategia de protección y transferencia de un método de diagnóstico y pronóstico de la sepsis y el shock séptico.
Investigador/a Principal FEDERICO VICENTE PALLARDO CALATAYUD
INNVA1/2020/85 . AGENCIA VALENCIANA DE INNOVACIÓN ( AVI ) . 2020
Test basados en péptidos spike-in y espectrometría de masas para la cuantificación de histonas circulantes y proteína APC, para el manejo clínico del paciente crítico.
Investigador/a Principal JOSE LUIS GARCIA GIMENEZ
DTS21/00193 . INSTITUTO SALUD CARLOS III . 2022
Cita
The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation. Cánovas I, Nacher E, Osca R, Dolz E, Beltrán J, Rodríguez M, Ferrando C et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023 enero 30. 24 (3):DOI:10.3390/ijms24032582. PMID:36768905.
