Portal de investigación
Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Galvez-Fernandez, Marta
- Rodriguez-Hernandez, Zulema
- Amigo, Nuria
- Garcia-Barrera, Tamara
- Gomez-Ariza, Jose L
- Briongos-Figuero, Laisa S
- Perez-Castrillon, Jose L
- Tellez-Plaza, Maria
- Martin-Escudero, Juan C
Grupos y Plataformas de I+D+i
Abstract
Background: The potential joint influence of metabolites on bone fragility has been rarely evaluated. We assessed the association of plasma metabolic patterns with bone fragility endpoints (primarily, incident osteoporosisrelated bone fractures, and, secondarily, bone mineral density BMD) in the Hortega Study participants. Redox balance plays a key role in bone metabolism. We also assessed differential associations in participant subgroups by redox-related metal exposure levels and candidate genetic variants. Material and methods: In 467 participants older than 50 years from the Hortega Study, a representative sample from a region in Spain, we estimated metabolic principal components (mPC) for 54 plasma metabolites from NMR-spectrometry. Metals biomarkers were measured in plasma by AAS and in urine by HPLC-ICPMS. Redoxrelated SNPs (N = 341) were measured by oligo-ligation assay. Results: The prospective association with incident bone fractures was inverse for mPC1 (non-essential and essential amino acids, including branched-chain, and bacterial co-metabolites, including isobutyrate, trimethylamines and phenylpropionate, versus fatty acids and VLDL) and mPC4 (HDL), but positive for mPC2 (essential amino acids, including aromatic, and bacterial co-metabolites, including isopropanol and methanol). Findings from BMD models were consistent. Participants with decreased selenium and increased antimony, arsenic and, suggestively, cadmium exposures showed higher mPC2-associated bone fractures risk. Genetic variants annotated to 19 genes, with the strongest evidence for NCF4, NOX4 and XDH, showed differential metabolic-related bone fractures risk. Conclusions: Metabolic patterns reflecting amino acids, microbiota co-metabolism and lipid metabolism were associated with bone fragility endpoints. Carriers of redox-related variants may benefit from metabolic interventions to prevent the consequences of bone fragility depending on their antimony, arsenic, selenium, and, possibly, cadmium, exposure levels.
Datos de la publicación
- ISSN/ISSNe:
- 0891-5849, 1873-4596
- Tipo:
- Article
- Páginas:
- 52-61
- PubMed:
- 36370960
FREE RADICAL BIOLOGY AND MEDICINE ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- Metabolomics; Bone mineral density; Osteoporosis -related bone fractures; Candidate genes; Metals; Redox
Financiación
Proyectos y Estudios Clínicos
Estudio de los factores implicados en el desarrollo de enfermedades de alto riesgo cardiovascular y sus complicaciones
Investigador Principal: RAFAEL CARMENA RODRIGUEZ
PROMETEO2009/029 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2011
Identificación de variaciones de secuencia y de metilación e hidroximetilación en el exoma asociadas al desarrollo de diabetes tipo 2.
Investigador Principal: FELIPE JAVIER CHAVES MARTÍNEZ
2014/1283 . INSTITUTO SALUD CARLOS III . 2015
Cita
Galvez M,Rodriguez Z,Grau M,Chaves FJ,Garcia AB,Amigo N,Monleon D,Garcia T,Gomez JL,Briongos LS,Perez JL,Redon J,Tellez M,Martin JC. Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study. Free Radic. Biol. Med. 2023. 194. p. 52-61. IF:7,100. (1).
Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study. Galvez M, Rodriguez Z, Grau M, Chaves FJ, Garcia AB, Amigo N, Monleon D et al. FREE RADICAL BIOLOGY AND MEDICINE. 2023 enero 01. 19452-61. DOI:10.1016/j.freeradbiomed.2022.11.007. PMID:36370960.
