Long-Term Prognostic Impact of Estimated Glomerular Filtration Rate on Admission in Patients Hospitalized for Acute Heart Failure.

Autores de INCLIVA

• 

  Rafael De La Espriella Juan

  Autor

• 

  Jorge Navarro Perez

  Autor

• Anna Mireia Mollar Fernandez

  Autor

• Patricia Palau Sampio

  Autor

• Gema Miñana Escriva

  Autor

• Enrique Santas Olmeda

  Autor

• Raquel Heredia Cambra

  Autor

• 

  Miguel Angel Gonzalez Rico

  Autor

• 

  Jose Luis Górriz Teruel

  Autor

• 

  Julio Nuñez Villota

  Autor

Participantes ajenos a INCLIVA

• D'Marco, Luis
• Llacer, Pau
• Codina, Pau
• Diez, Javier
• Bayes-Genis, Antoni

Grupos y Plataformas de I+D+i

• Grupo de Enfermedad Renal

  

  Leading Researcher

  Jose Luis Górriz Teruel

• Grupo de investigación cardiometabólica en atención primaria

  

  Leading Researcher

  Jorge Navarro Perez

• Grupo de investigación en Cardiología Clínica

  

  Leading Researcher

  Juan Sanchis Fores

• Grupo de Investigación en Insuficiencia Cardiaca

  

  Established Researcher

  Julio Nuñez Villota

Abstract

INTRODUCTION: Although small-sample size studies have shown that basal alterations of estimated glomerular filtration rate (eGFR) are related to short- and mid-term higher mortality in acute heart failure (AHF), there is scarce information on the influence of an altered eGFR on long-term mortality and readmissions. Therefore, this multicenter study sought to investigate the relationship between eGFR on admission for AHF and both long-term mortality and readmissions in a large sample of patients. METHODS: We retrospectively evaluated 4,595 patients consecutively discharged after admission for AHF at three tertiary-care hospitals from January 1, 2008, to January 1, 2020. To investigate the effect of eGFR on admission with long-term morbimortality, we stratified the patients according to four eGFR categories: <30 mL·min-1·1.73 m-2 (G4 and G5 patients, n = 534), 30-44 mL·min-1·1.73 m-2 (G3b patients, n = 882), 45-59 mL·min-1·1.73 m-2 (G3a patients, n = 1,080), and =60 mL·min-1·1.73 m-2 (G1 and G2 patients, n = 2,099). eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation within the first 24 h following admission. RESULTS: At a median follow-up of 2.20 years, multivariate analyses revealed that compared to G1 and G2 patients, G4 and G5 patients exhibited a higher risk of all-cause (HR = 1.15, 95% CI: 01.02-1.30, p = 0.020) and cardiovascular (CV) (HR = 1.20, 95% CI: 1.04-1.39, p = 0.013) mortality. Similarly, multivariate analyses also showed that the lower the eGFR, the higher the risk of readmissions. In fact, compared to G1 and G2 patients, G4 and G5 patients displayed significantly increased incident rate ratios of total all-cause (28%), CV (26%), and HF-related (30%) readmissions. CONCLUSION: Data from this large study provide evidence that an eGFR below 30 mL·min-1·1.73 m-2 on admission could be an independent predictor for long-term mortality and readmissions in patients with AHF.

© 2022 The Author(s). Published by S. Karger AG, Basel.

Keywords

• Acute heart failure; Glomerular filtration rate; Mortality; Prognosis; Readmissions