Portal de investigación
A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Gimenez-Garzo, C
- Benlloch, S
- Rios, MP
- Durban, L
- Aparicio, L
- Felipo, V
Grupos y Plataformas de I+D+i
Abstract
Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The neurological functions affected remain unclear. The aims were to: (1) Characterize the neuropsychological alterations in NAFLD patients; (2) assess the prevalence of impairment of neurological functions evaluated; (3) develop a new score for sensitive and rapid MCI detection in NAFLD; (4) assess differences in MCI features between patients with nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); and (5) compare neuropsychological alterations in NAFLD patients with cirrhotic patients with MCI. Fifty-nine NAFLD patients and 53 controls performed psychometric tests assessing different neurological functions: PHES (Psychometric Hepatic Encephalopathy Score) battery, d2, Stroop, Oral SDMT (Symbol Digit Modalities Test), Digit Span, number-letter test, and bimanual and visual-motor coordination tests. NAFLD patients show impairment in attention, mental concentration, psychomotor speed, cognitive flexibility, inhibitory mental control, and working memory. We developed a new, rapid, and sensitive score based on the most affected parameters in NAFLD patients, unveiling that 32% of NAFLD show MCI. Prevalence was similar in NAFL (36%) or NASH (27%) patients, but lower in NAFLD than in cirrhosis (65%). MCI prevalence is significant in NAFLD patients. Psychometric testing is warranted in these patients to unveil MCI and take appropriate measures to reverse and prevent its progression.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm10132806
- PubMed:
- 34202269
Journal of Clinical Medicine MDPI
Citas Recibidas en Web of Science: 19
Documentos
Filiaciones
Keywords
- NAFL; NAFLD; NASH; neurological impairment; psychometric score
Financiación
Proyectos y Estudios Clínicos
Caracterización de las alteraciones neurológicas en pacientes con encefalopatía hepática mínima. Estudio de mecanismos implicados.
Investigador Principal: JUAN JOSÉ GALLEGO ROIG
ACIF/2018/284 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2018
ESTUDIO DE LAS ALTERACIONES NEUROLÓGICAS, CEREBRALES Y BIOQUÍMICAS EN PACIENTES CON ENFERMEDAD GRASA DEL HÍGADO. MECANISMOS MOLECULARES Y CELULARES.
Investigador Principal: FRANC CASANOVA FERRER
ACIF/2019/232 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO
CONTRATOS RIO HORTEGA 2019
Investigador Principal: MARIA PILAR BALLESTER FERRE
CM19/00011 . INSTITUTO SALUD CARLOS III . 2020
Cita
Gimenez C,Fiorillo A,Ballester MP,Gallego JJ,Casanova F,Urios A,Benlloch S,Marti D,San T,Tosca J,Rios MP,Monton C,Durban L,Escudero D,Aparicio L,Felipo V,Montoliu C. A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease. J. Clin. Med. 2021. 10. (13):2806. IF:4,964. (2).
A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease. Gimenez C, Fiorillo A, Ballester MP, Gallego JJ, Casanova F, Urios A, Benlloch S et al. Journal of Clinical Medicine. 2021 junio 25. 10 (13):DOI:10.3390/jcm10132806. PMID:34202269.
