Portal de investigación
Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Usategui-Martin, Ricardo
- Perez-Castrillon, Jose Luis
- Mansego, Maria L
- Lara-Hernandez, Francisco
- Manzano, Iris
- Briongos, Laisa
- Abadia-Otero, Jesica
- Martin-Vallejo, Javier
- Martin-Escudero, Juan Carlos
Grupos y Plataformas de I+D+i
Abstract
The most widely accepted etiopathogenesis hypothesis of the origin of osteoporosis and its complications is that they are a consequence of bone aging and other environmental factors, together with a genetic predisposition. Evidence suggests that oxidative stress is crucial in bone pathologies associated with aging. The aim of this study was to determine whether genetic variants in oxidative stress-related genes modified the risk of osteoporotic fracture. We analysed 221 patients and 354 controls from the HORTEGA sample after 12-14 years of follow up. We studied the genotypic and allelic distribution of 53 SNPs in 24 genes involved in oxidative stress. The results showed that being a carrier of the variant allele of the SNP rs4077561 within TXNRD1 was the principal genetic risk factor associated with osteoporotic fracture and that variant allele of the rs1805754 M6PR, rs4964779 TXNRD1, rs406113 GPX6, rs2281082 TXN2 and rs974334 GPX6 polymorphisms are important genetic risk factors for fracture. This study provides information on the genetic factors associated with oxidative stress which are involved in the risk of osteoporotic fracture and reinforces the hypothesis that genetic factors are crucial in the etiopathogenesis of osteoporosis and its complications.
Copyright © 2021 Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0378-1119, 1879-0038
- Tipo:
- Article
- Páginas:
- 146036-146036
- PubMed:
- 34688818
Gene Elsevier BV
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- Aging; Bone metabolism; Fracture; Osteoporosis; Oxidative stress; Reactive oxygen species
Financiación
Proyectos y Estudios Clínicos
Identificación de variaciones de secuencia y de metilación e hidroximetilación en el exoma asociadas al desarrollo de diabetes tipo 2.
Investigador Principal: FELIPE JAVIER CHAVES MARTÍNEZ
2014/1283 . INSTITUTO SALUD CARLOS III . 2015
Identificación de variantes genéticas protectoras frente al desarrollo de diabetes tipo 2 en octogenarios.
Investigador Principal: FELIPE JAVIER CHAVES MARTÍNEZ
PI17/00544 . INSTITUTO SALUD CARLOS III . 2018
Cita
Usategui R,Perez JL,Mansego ML,Lara F,Manzano I,Briongos L,Abadia J,Martin J,Garcia AB,Martin JC,Chaves FJ. Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study. Gene. 2022. 809. p. 146036-146036. IF:3,500. (2).
Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study. Usategui R, Perez JL, Mansego ML, Lara F, Manzano I, Briongos L, Abadia J et al. Gene. 2022 enero 30. 809146036-146036. DOI:10.1016/j.gene.2021.146036. PMID:34688818.
