Portal de investigación
Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Llacer, P
- Nunez, E
- Lupon, J
- Bayes-Genis, A
Grupos y Plataformas de I+D+i
Abstract
Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure (HF). In AHF syndromes, CA125 is strongly associated with right-sided HF parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated HF event. The wide availability of CA125 in most clinical laboratories, together with its standardized measurement and reduced cost, makes this marker attractive for routine use in decompensated HF. Further research is required to understand better its biological role and its promising utility as a tool to guide decongestive therapy in HF.
© 2021 European Society of Cardiology.
Datos de la publicación
- ISSN/ISSNe:
- 1388-9842, 1879-0844
- Tipo:
- Article
- Páginas:
- 1445-1457
- DOI:
- 10.1002/ejhf.2295
- PubMed:
- 34241936
EUROPEAN JOURNAL OF HEART FAILURE WILEY
Citas Recibidas en Web of Science: 111
Documentos
Filiaciones
Keywords
- CA125; Heart failure; MUC16
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Nunez J,de la Espriella R,Minana G,Santas E,Llacer P,Nunez E,Palau P,Bodi V,Chorro FJ,Sanchis J,Lupon J,Bayes A. Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review. Eur. J. Heart Fail. 2021. 23. (9):p. 1445-1457. IF:17,349. (1).
Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review. Nunez J, de la Espriella R, Minana G, Santas E, Llacer P, Nunez E, Palau P et al. EUROPEAN JOURNAL OF HEART FAILURE. 2021 septiembre 01. 23 (9):1445-1457. DOI:10.1002/ejhf.2295. PMID:34241936.
