Portal de investigación
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Eritja, N
- de Andrea, C
- Diaz-Martin, J
- Diaz-Lagares, A
- Jacome, MA
- Salguero-Aranda, C
- Ros, DG
- Davidson, B
- Lopez, R
- Melero, I
- Cajal, SRY
- de Alava, E
- Matias-Guiu, X
Grupos y Plataformas de I+D+i
Abstract
The invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.
Copyright © 2021 Sanegre, Eritja, de Andrea, Diaz-Martin, Diaz-Lagares, Jácome, Salguero-Aranda, García Ros, Davidson, Lopez, Melero, Navarro, Ramon y Cajal, de Alava, Matias-Guiu and Noguera.
Datos de la publicación
- ISSN/ISSNe:
- 2296-634X, 2296-634X
- Tipo:
- Article
- Páginas:
- 670185-670185
- PubMed:
- 34150764
Frontiers in Cell and Developmental Biology Frontiers Media S.A.
Citas Recibidas en Web of Science: 9
Documentos
Filiaciones
Keywords
- epigenetic profiles; extracellular matrix; gene expression; immune cells; reticular fibers; tumor microenvironment; tumor-host interface
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: ANA LLUCH HERNÁNDEZ
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INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: ROSA NOGUERA SALVA
CB16/12/00484 . INSTITUTO SALUD CARLOS III
Identificación y validación de nuevas terapias, modelos preclínicos y marcadores de respuesta terapéutica en neuroblastoma. (PI17/01558).
Investigador Principal: ROSA NOGUERA SALVA
PI17/01558 . INSTITUTO SALUD CARLOS III . 2018
Neuroblastoma: estrategias mecanoterapéuticas basadas en modelos 3D y tumores derivados de pacientes con microambiente rico en vitronectina
Investigador Principal: ROSA NOGUERA SALVA
PI20/01107 . INSTITUTO SALUD CARLOS III . 2021
Cita
Sanegre S,Eritja N,de Andrea C,Diaz J,Diaz A,Jacome MA,Salguero C,Ros DG,Davidson B,Lopez R,Melero I,Navarro S,Cajal SRY,de Alava E,Matias X,Noguera R. Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma. Front. Cell. Dev. Biol. 2021. 9. p. 670185-670185. IF:6,081. (1).
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma. Sanegre S, Eritja N, de Andrea C, Diaz J, Diaz A, Jacome MA, Salguero C et al. Frontiers in Cell and Developmental Biology. 2021 junio 03. 9670185-670185. DOI:10.3389/fcell.2021.670185. PMID:34150764.
