Portal de investigación
Right ventricular function and iron deficiency in acute heart failure.
Fecha de publicación:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Nunez, Eduardo
- Cohen-Solal, Alain
- Bayes-Genis, Antoni
Grupos y Plataformas de I+D+i
Abstract
AIMS: Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF. METHODS AND RESULTS: We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE/pulmonary artery systolic pressure (TAPSE/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin <100 mg/dL (absolute ID) or ferritin 100-299 mg/dL and transferrin saturation (TSAT) <20% (functional ID). The relationships among the exposures with right ventricular systolic function were evaluated by multivariate linear regression analyses. The mean age of the sample was 74.3 ± 10.6 years, 441 (48.8%) were female, 471 (52.2%) exhibited heart failure with preserved ejection fraction, and 677 (75.0%) showed ID. The mean LVEF, TAPSE, and TAPSE/PASP were 49 ± 15%, 18.6 ± 3.9 mm, and 0.45 ± 0.18, respectively. The median (interquartile range) amino-terminal pro-brain natriuretic peptide was 4015 (1807-8775) pg/mL. In a multivariable setting, lower TSAT and ferritin were independently associated with lower TAPSE (P < 0.05 for both comparisons). Transferrin saturation (P = 0.017), and not ferritin (P = 0.633), was independently associated with TAPSE/PASP. CONCLUSION: In AHF, proxies of ID were associated with right ventricular dysfunction. Further studies should confirm these findings and evaluate the pathophysiological facts behind this association.
© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.
Datos de la publicación
- ISSN/ISSNe:
- 2048-8726, 2048-8734
- Tipo:
- Article
- Páginas:
- 406-414
- PubMed:
- 33620455
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE SAGE PUBLICATIONS LTD
Citas Recibidas en Web of Science: 11
Documentos
Filiaciones
Keywords
- Left ventricle ejection fraction; Right ventricle ejection fraction; Tricuspid annular plane systolic excursion; Iron deficiency
Financiación
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo de miocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b (PI17/01836).
Investigador Principal: VICENT BODÍ PERIS
PI17/01836 . INSTITUTO SALUD CARLOS III . 2018
Cita
Minana G,Santas E,de la Espriella R,Nunez E,Lorenzo M,Nunez G,Valero E,Bodi V,Chorro FJ,Sanchis J,Cohen A,Bayes A,Nunez J. Right ventricular function and iron deficiency in acute heart failure. Eur. Heart J.-Acute Cardiovasc. Care. 2021. 10. (4):p. 406-414. IF:4,766. (2).
Right ventricular function and iron deficiency in acute heart failure. Minana G, Santas E, de la Espriella R, Nunez E, Lorenzo M, Nunez G, Valero E et al. EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE. 2021 mayo 25. 10 (4):406-414. DOI:10.1093/ehjacc/zuaa028. PMID:33620455.
