Portal de investigación
Homocysteine and long-term recurrent infarction following an acute coronary syndrome.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Gil-Cayuela, Carolina
- Facila, Lorenzo
- Marco, Maria
- Garcia-Ballester, Teresa
- Zorio, Begona
- Marti-Cervera, Jorge
- Nunez, Eduardo
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: There are no well-established predictors of recurrent ischemic coronary events after an acute coronary syndrome (ACS). Higher levels of homocysteine have been reported to be associated with an increased atherosclerotic burden. The primary endpoint was to assess the relationship between homocysteine at discharge and very long-term recurrent myocardial infarction (MI). METHODS: 1306 consecutive patients with ACS were evaluated (862 with non-ST-segment elevation ACS [NSTEACS] and 444 with ST-segment elevation myocardial infarction [STEMI]) discharged from October 2000 to June 2003 in a single teaching-center. The relationship between homocysteine at discharge and recurrent MI was evaluated through bivariate negative binomial regression accounting for mortality as a competitive event. RESULTS: The mean age was 66.8 ± 12.4 years, 69.1% were men, and 32.2% showed prior diabetes mellitus. Most of the patients were admitted for an NSTEACS (66.0%). The median (interquartile range) GRACE risk score, Charlson comorbidity index, and homocysteine were 144 (122-175) points, 1 (1-2) points, and 11.9 (9.3-15.6) µmol/L, respectively. In-hospital revascularization was performed in 26.3% of patients. At a median follow-up of 9.7 (4.5-15.1) years, 709 (54.3%) deaths were registered and 779 recurrent MI in 478 (36.6%) patients. The rates of recurrent MI were higher in patients in the upper homocysteine quartiles (p < 0.001). After a multivariate adjustment, homocysteine along its continuum remained almost linearly associated with a higher risk of recurrent MI (p = 0.001) and all-cause mortality (p < 0.001). CONCLUSIONS: In patients with ACS, higher homocysteine levels identified those at a higher risk of recurrent MI at very long-term follow-up.
Datos de la publicación
- ISSN/ISSNe:
- 1897-5593, 1898-018X
- Tipo:
- Article
- Páginas:
- 598-606
- PubMed:
- 33346372
Cardiology Journal Via Medica
Citas Recibidas en Web of Science: 6
Documentos
Filiaciones
Keywords
- acute coronary syndrome; coronary artery disease; homocysteine; recurrent myocardial infarction; risk factors
Financiación
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo de miocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b (PI17/01836).
Investigador Principal: VICENT BODÍ PERIS
PI17/01836 . INSTITUTO SALUD CARLOS III . 2018
Cita
Minana G,Gil C,Facila L,Bodi V,Valero E,Mollar A,Marco M,Garcia T,Zorio B,Marti J,Nunez E,Chorro FJ,Sanchis J,Nunez J. Homocysteine and long-term recurrent infarction following an acute coronary syndrome. Cardiol J. 2021. 28. (4):p. 598-606. IF:3,487. (2).
Homocysteine and long-term recurrent infarction following an acute coronary syndrome. Minana G, Gil C, Facila L, Bodi V, Valero E, Mollar A, Marco M et al. Cardiology Journal. 2021 enero 01. 28 (4):598-606. DOI:10.5603/CJ.a2020.0170. PMID:33346372.
