Portal de investigación
Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction.
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Bayes-Genis, Antoni
- Revuelta, Elena
- Llacer, Pau
- Ventura, Silvia
- Sanchez, Ruth
- Cordero, Alberto
- Facila, Lorenzo
- IMPROVE-HF Investigators
Grupos y Plataformas de I+D+i
Abstract
BACKGROUND: Identifying patients at risk of poor diuretic response in acute heart failure (AHF) is critical to make prompt adjustments in therapy. The objective of this study was to investigate whether the circulating levels of soluble ST2 predict the cumulative diuretic efficiency (DE) at 24 and 72 hours in patients with AHF and concomitant renal dysfunction. METHODS AND RESULTS: This is a post hoc analysis of the IMPROVE-HF trial, in which we enrolled 160 patients with AHF and renal dysfunction (estimated glomerular filtrate rate of <60 mL/min/1.73 m(2)). DE was calculated as the net fluid output produced per 40 mg of furosemide equivalents. The association between sST2 and DE was evaluated by using multivariate linear regression analysis. The median cumulative DE at 24 and 72 hour was 747 mL (interquartile range 490-1167 mL) and 1844 mL (interquartile range 1142-2625 mL), respectively. The median sST2 and mean estimated glomerular filtrate rate were 72 ng/mL (interquartile range 47-117 ng/mL), and 34.0 ± 8.5 mL/min/1.73 m(2), respectively. In a multivariable setting, higher sST2 were significant and nonlinearly related to lower DE both at 24 and 72 hours (P?=?.002 and P?=?.019, respectively). CONCLUSIONS: In patients with AHF and renal dysfunction at presentation, circulating levels of sST2 were independently and negatively associated with a poor diuretic response, both at 24 and 72 hours.
Copyright © 2020 Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 1071-9164, 1532-8414
- Tipo:
- Article
- Páginas:
- 427-434
- PubMed:
- 33038531
JOURNAL OF CARDIAC FAILURE CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
Citas Recibidas en Web of Science: 12
Documentos
- No hay documentos
Filiaciones
Keywords
- Acute heart failure; Congestion; Diuretic efficiency; Renal dysfunction; sST2
Financiación
Proyectos y Estudios Clínicos
Dosificación de diuréticos de asa en pacientes con insuficiencia cardiaca aguda e insuficiencia renal: Estrategia convencional versus estrategia guiada por niveles plasmáticos de CA 125.
Investigador Principal: JULIO NUÑEZ VILLOTA
PI13/01519 . INSTITUTO SALUD CARLOS III . 2014
Plataforma de Unidades de Investigación Clínica y Ensayos Clinicos.
Investigador Principal: ANDRÉS CERVANTES RUIPEREZ
PT13/0002/0031 . INSTITUTO SALUD CARLOS III . 2014
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: JUAN SANCHIS FORES
CB16/11/00420 . INSTITUTO SALUD CARLOS III
Cita
Espriella RL,Bayes A,Revuelta E,Minana G,Santas E,Llacer P,Garcia S,Fernandez A,Bonanad C,Ventura S,Sanchez R,Bodi V,Cordero A,Facila L,Mollar A,Sanchis J,IMPROVE I,Nunez J. Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction. J. Card. Fail. 2021. 27. (4):p. 427-434. IF:6,592. (2).
Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction. Espriella RL, Bayes A, Revuelta E, Minana G, Santas E, Llacer P, Garcia S et al. JOURNAL OF CARDIAC FAILURE. 2021 abril 01. 27 (4):427-434. DOI:10.1016/j.cardfail.2020.10.002. PMID:33038531.
