The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects.

Autores de INCLIVA

• 

  Clara Bonanad Lozano

  Autor

• Sergio Garcia Blas

  Autor

• 

  Juan Sanchis Fores

  Autor

• Ruben Facila De La Esperanza

  Autor

• 

  Julio Nuñez Villota

  Autor

Participantes ajenos a INCLIVA

• Tarazona-Santabalbina, Francisco
• Bertomeu-Gonzalez, Vicente
• Ariza, Albert
• Cordero, Alberto

Grupos y Plataformas de I+D+i

• Grupo de investigación en Cardiología Clínica

  

  Leading Researcher

  Juan Sanchis Fores

• Grupo de Investigación en Insuficiencia Cardiaca

  

  Established Researcher

  Julio Nuñez Villota

• Grupo de Investigación Traslacional en Cardiopatía Isquémica

  

  Leading Researcher

  Vicent Bodí Peris

Abstract

OBJECTIVES: Initial data on COVID-19 infection has pointed out a special vulnerability of older adults.; DESIGN: We performed a meta-analysis with available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom, and New York State. Analyses were performed by a random effects model, and sensitivity analyses were performed for the identification of potential sources of heterogeneity.; SETTING AND PARTICIPANTS: COVID-19-positive patients reported in literature and national reports.; MEASURES: All-cause mortality by age.; RESULTS: A total of 611,1583 subjects were analyzed and 141,745 (23.2%) were aged =80years. The percentage of octogenarians was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State. The overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%). Mortality was <1.1% in patients aged <50years and it increased exponentially after that age in the 5 national registries. As expected, the highest mortality rate was observed in patients aged =80years. All age groups had significantly higher mortality compared with the immediately younger age group. The largest increase in mortality risk was observed in patients aged 60 to 69years compared with those aged 50 to 59years (odds ratio 3.13, 95% confidence interval 2.61-3.76).; CONCLUSIONS AND IMPLICATIONS: This meta-analysis with more than half million of COVID-19 patients from different countries highlights the determinant effect of age on mortality with the relevant thresholds on age >50years and, especially, >60years. Older adult patients should be prioritized in the implementation of preventive measures. Copyright © 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

© 2020 AMDA e The Society for Post-Acute and Long-Term Care Medicine

Keywords

• COVID-19, coronavirus, mortality, older adults