Portal de investigación
Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications.
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Rodriguez-Palomares, Jose F
- Valente, Filipa
- Monmeneu, Jose V
- Lopez-Lereu, Maria P
- Ferreira-Gonzalez, Ignacio
- Garcia Del Blanco, Bruno
- Otaegui, Imanol
- Perez, Nerea
- Barrabes, Jose A
- Evangelista, Arturo
- Moratal, David
- Bayes-Genis, Antoni
Grupos y Plataformas de I+D+i
Abstract
PURPOSE: In ST-segment elevation myocardial infarction (STEMI) patients, longitudinal strain (LS) in remote non-infarcted myocardium (RNM) has not yet been characterized by tissue tracking (TT) cardiovascular magnetic resonance (CMR). In STEMI patients, we aimed to characterize RNM-LS by TT-CMR and to assess both its dynamics and its structural and prognostic implications. METHODS: We recruited 271 patients with a first STEMI studied with TT-CMR 1 week after infarction. Of these patients, 145 underwent 1-week and 6-month TT-CMR and were used to characterize both the dynamics and the short-term and long-term structural implications of RNM-LS. Based on previously validated data, RNM areas were defined depending on the culprit coronary artery. RESULTS: Reduced RNM-LS at 1 week (n = 70, 48%) was associated with larger infarct size and more depressed left ventricular ejection fraction (LVEF) at both the 1-week and 6-month TT-CMR (p value < 0.001). Late normalization of RNM-LS was frequent (28/70, 40%) and independently related to late recovery of LVEF (p value = 0.002). Patients with reduced RNM-LS at 1-week TT-CMR had more major adverse cardiac events (death, heart failure or re-infarction) in both the 271 patients included in the study group (26% vs. 11%, p value = 0.002) and in an external validation cohort made up of 177 STEMI patients (57% vs. 13%, p value < 0.001). CONCLUSION: After STEMI, reduced RNM-LS by TT-CMR is common and is associated with more severe short- and long-term structural damage. There is a beneficial tendency towards recovery of RNM-LS that parallels late recovery of LVEF. More events occur in patients with reduced RNM-LS.
Datos de la publicación
- ISSN/ISSNe:
- 1569-5794, 1875-8312
- Tipo:
- Article
- Páginas:
- 241-253
- PubMed:
- 32488452
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING Kluwer Academic Publishers
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- Cardiovascular magnetic resonance; Myocardial infarction; Prognosis; Strain; Tissue tracking
Financiación
Proyectos y Estudios Clínicos
A multidisciplinary project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction.
Investigador Principal: VICENT BODÍ PERIS
PIE15/00013 . INSTITUTO SALUD CARLOS III . 2016
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: VICENT BODÍ PERIS
CB16/11/00486 . INSTITUTO SALUD CARLOS III
Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo de miocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b (PI17/01836).
Investigador Principal: VICENT BODÍ PERIS
PI17/01836 . INSTITUTO SALUD CARLOS III . 2018
Estudio multidisciplinar de la dinámica, mecanismos básicos, diagnóstico y exploración de nuevas oportunidades terapéuticas en la obstrucción...
Investigador Principal: CLARA BONANAD LOZANO
GV/2018/116 . CONSELLERIA EDUCACION/INNOVACION,UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL/EMPLEO . 2018
Un estudio multidisciplinar para avanzar en el entendimiento de los mecanismos básicos y la exploración de nuevas oportunidades terapéuticas en el infarto agudo de miocardio. Foco en los factores VEGF-A165b y ST2.
Investigador Principal: CÉSAR RIOS NAVARRO
FI18/00320 . INSTITUTO SALUD CARLOS III . 2019
Cita
Gavara J,Rodriguez JF,Rios C,Valente F,Monmeneu JV,Lopez MP,Ferreira I,Garcia Del Blanco B,Otaegui I,Canoves J,de Dios E,Perez N,Racugno P,Bonanad C,Minana G,Marcos V,Barrabes JA,Evangelista A,Moratal D,Bayes A,Nunez J,Chorro FJ,Bodi V. Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications. Int J Cardiovasc Imaging. 2021. 37. (1):p. 241-253. IF:2,316. (3).
Longitudinal strain in remote non-infarcted myocardium by tissue tracking CMR: characterization, dynamics, structural and prognostic implications. Gavara J, Rodriguez JF, Rios C, Valente F, Monmeneu JV, Lopez MP, Ferreira I et al. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING. 2021 enero 01. 37 (1):241-253. DOI:10.1007/s10554-020-01890-w. PMID:32488452.
