Portal de investigación
Risk of developing neuroblastoma influenced by maternal stressful life events during pregnancy and congenital pathologies
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Benavent N
- Cañete A
- Moreno L
- Gros L
- Salinas JA
- Álvaro T
- Tadeo I
Grupos y Plataformas de I+D+i
Abstract
ObjectiveA retrospective multicenter study to investigate the potential association between descriptive information related to pregnancy history and perinatal features and the risk of neuroblastoma (NB) in children.Study designData from 56 mothers during 105 pregnancies (56 cases of NB, 49 control siblings) were collected through face-to-face or telephone interviews with mothers of children diagnosed with NB, along with information extracted from Health System databases. Descriptive information related to (a) pregnancy history as maternal stressful life events with perceived distress during pregnancy, weight gain, alcohol and tobacco consumption, mode of delivery and gestational age; and (b) perinatal features as congenital pathologies, weight at birth and type of feeding were examined to identify potential risk factors for NB.ResultsStressful life events during pregnancy and certain congenital pathologies were independently associated with NB risk. No significant associations were found between other features. Breastfeeding rates were similar between cases and controls.ConclusionOur results underscore the importance of providing support and care to pregnant women to reduce potential stressors. Further research is needed to better understand the influence of dysbiosis and mitochondrial-nuclear communication impairment as underlying mechanisms of maternal stress during pregnancy and presence of congenital pathologies in order to confirm them as potential risk factors for NB.
© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.
Datos de la publicación
- ISSN/ISSNe:
- 1545-5009, 1545-5017
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1002/pbc.31402
- PubMed:
- 39618320
PEDIATRIC BLOOD & CANCER WILEY
Documentos
- No hay documentos
Filiaciones
Keywords
- maternal stress; pregnancy; neuroblastoma; childhood cancer; perinatal events
Financiación
Proyectos y Estudios Clínicos
INCORPORACIÓN DE NUEVAS ÁREAS TEMÁTICAS Y NUEVOS GRUPOS AL CONSORCIO CIBER
Investigador Principal: ROSA NOGUERA SALVA
CB16/12/00484 . INSTITUTO SALUD CARLOS III
Neuroblastoma: estrategias mecanoterapéuticas basadas en modelos 3D y tumores derivados de pacientes con microambiente rico en vitronectina
Investigador Principal: ROSA NOGUERA SALVA
PI20/01107 . INSTITUTO SALUD CARLOS III . 2021
Cita
Benavent N,Cañete A,Moreno L,Gros L,Verdú J,Salinas JA,Navarro S,Álvaro T,Carbonell JA,Noguera R,Tadeo I. Risk of developing neuroblastoma influenced by maternal stressful life events during pregnancy and congenital pathologies. Pediatr. Blood Cancer. 2025. 72. (2):e31402. IF:2,300. (2).
Risk of developing neuroblastoma influenced by maternal stressful life events during pregnancy and congenital pathologies. Benavent N, Cañete A, Moreno L, Gros L, Verdú J, Salinas JA, Navarro S et al. PEDIATRIC BLOOD & CANCER. 2025 febrero 01. 72 (2):DOI:10.1002/pbc.31402. PMID:39618320.
