Portal de investigación
Light deficiency in Apoe-/-mice increases atheroma plaque size and vulnerability by modulating local immunity.
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Herrero-Cervera, A
- Vinué, A
- Martín-Vañó, S
- Taberner-Cortés, A
Grupos y Plataformas de I+D+i
Abstract
Previous research suggests a potential involvement of the cytokine LIGHT (TNFSF14) in atherosclerosis. In this study, the genetic inactivation of Light in Apolipoprotein E deficient mice (male and female C57BL) augmented plaque size and vulnerability while decreasing Treg cells. Human and mouse transcriptomic results demonstrated deranged immune pathways in human atheromas with low LIGHT expression levels and in Light-deficient murine atheromas. In agreement with this, in vitro LIGHT-treatment of human lymphocytes, induced an elevation of Treg cell prevalence while proteomic analysis showed a downregulation of apoptotic and leukocyte cytotoxic pathways. Consistently, Light-deficient mouse lesions displayed increased plaque apoptosis and detrimental adventitial T-lymphocyte aggregates. Altogether suggested that LIGHT could promote a Treg prevalence in the local immunity to prevent the generation of vulnerable plaques via decreased cytotoxic microenvironment and apoptosis. Light gene delivery in Apoe-/-Light-/- mice, through bone marrow transplantation approaches, consistently diminished lesion size and restored local plaque immunity. Altogether demonstrate that Light-deficiency promotes atheroma plaque progression, at least in part through local loss of immune homeostasis and increased apoptosis. This study suggest that therapies based on the local delivery of LIGHT within plaques might therefore prevent immune cell derangement and advanced atherosclerosis.
Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0925-4439, 1879-260X
- Tipo:
- Article
- Páginas:
- 167052-167052
- PubMed:
- 38336102
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE ELSEVIER SCIENCE BV
Documentos
- No hay documentos
Filiaciones
Keywords
- Atherosclerosis; Inflammation; Lymphocyte; T cells
Financiación
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Cita
Hurtado G,Herrero A,Vinué A,Martín S,Aguilar M,Taberner A,Jiménez E,Martínez S,González H. Light deficiency in Apoe-/-mice increases atheroma plaque size and vulnerability by modulating local immunity. Biochim. Biophys. Acta-Mol. Basis Dis. 2024. 1870. (4):p. 167052-167052. IF:4,200. (1).
Light deficiency in Apoe-/-mice increases atheroma plaque size and vulnerability by modulating local immunity. Hurtado G, Herrero A, Vinué A, Martín S, Aguilar M, Taberner A, Jiménez E et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024 abril 01. 1870 (4):167052-167052. DOI:10.1016/j.bbadis.2024.167052. PMID:38336102.
