Effect of exercise training in patients with chronotropic incompetence and heart failure with preserved ejection fraction: Training-HR study protocol

Autores de INCLIVA

• 

  Patricia Palau Sampio

  Autor

• 

  Julio Núñez Villota

  Autor

• Eloy Dominguez Mafé

  Autor

• 

  Rafael De La Espriella Juan

  Autor

• 

  Gonzalo Núñez Marín

  Autor

• 

  Juan Sanchis Fores

  Autor

• 

  Laura Lopez Bueno

  Autor

Participantes ajenos a INCLIVA

• Flor C
• de Amo I
• Casaña J
• Calatayud J
• Ortega L
• Marín P
• Sanchis-Gomar F

Grupos y Plataformas de I+D+i

• Grupo de Investigación en Cardiología Clínica

  

  Leading Researcher

  Juan Sanchis Fores

• Grupo de Investigación en Insuficiencia Cardiaca

  

  Established Researcher

  Julio Núñez Villota

Abstract

Background: Chronotropic incompetence (ChI) is linked with diminished exercise capacity in heart failure with preserved ejection fraction (HFpEF). Although exercise training has shown potential for improving functional capacity, the exercise modality associated with greater functional and chronotropic response (ChR) is not well-known. Additionally, how the ChR from different exercise modalities mediates functional improvement remains to be determined. This study aimed to evaluate the effect of three different exercise programs over current guideline recommendations on peak oxygen consumption (peakVO2) in patients with ChI HFpEF phenotype. Methods and results: In this randomized clinical trial, 80 stable symptomatic patients with HFpEF and ChI (NYHA class II-III/IV) are randomized (1:1:1:1) to receive: a) a 12-week program of supervised aerobic training (AT), b) AT and low to moderate-intensity strength training, c)AT and moderate to high-intensity strength training, or d) guideline-based physical activity and exercise recommendations. The primary endpoint is 12-week changes in peakVO(2). The secondary endpoints are 12-week changes in ChR, 12-week changes in quality of life, and how ChR changes mediate changes in peakVO(2). A mixed-effects model for repeated measures will be used to compare endpoint changes. The mean age is 75.1 +/- 7.2 years, and most patients are women (57.5 %) in New York Heart Association functional class II (68.7 %). The mean peakVO(2), percent of predicted peakVO(2), and ChR are 11.8 +/- 2.6 mL/kg/min, 67.2 +/- 14.7 %, and 0.39 +/- 0.16, respectively. No significant baseline clinical differences between arms are found. Conclusions: Training-HR will evaluate the effects of different exercise-based therapies on peakVO(2), ChR, and quality of life in patients with ChI HFpEF phenotype.

Copyright © 2024 Elsevier Inc. All rights reserved.

Keywords

• HFpEF; Chronotropic incompetence; Heart rate response; PeakVO(2)