Portal de investigación
Key role of activated platelets in the enhanced adhesion of circulating leucocyte-platelet aggregates to the dysfunctional endothelium in early-stage COPD
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Marques P
- Bocigas I
- Francisco V
- Garcia-Sanjuan Y
Grupos y Plataformas de I+D+i
Abstract
Background Chronic obstructive pulmonary disease (COPD), usually caused by long-term tobacco smoking, is independently associated with systemic inflammation. However, little is known about the systemic inflammatory status of patients with early-stage COPD (classified as GOLD 1) and long-term smokers with normal lung function (LF). Here, we characterised the early changes in the associated inflammatory state in patients with GOLD 1 and in long-term smokers with normal LF.Methods Fresh blood samples from 27 patients with GOLD 1, 27 long-term smokers and 14 non-smokers were analysed.Results Ex vivo blood analysis revealed greater leucocyte-platelet adhesion to TNF alpha-stimulated pulmonary endothelium in patients with GOLD 1 than in smokers and non-smokers. In addition, platelet reactivity (platelet count and activation, and fibrinogen levels) and the frequency of leucocyte-platelet aggregates were higher in the GOLD 1 group than in the other groups. Some of these findings correlated with the severity of lung dysfunction, while platelet hyperactivity correlated positively with leucocyte-platelet adhesion. The GOLD 1 group also had a higher Th17/Treg ratio and higher circulating levels of IL-17C and C-reactive protein than the other groups. However, long-term smokers also had higher leucocyte counts and activation, and higher plasma levels of TNF alpha and IL-6 than non-smokers.Conclusion Our data suggest that the altered inflammatory parameters in long-term smokers may represent early biomarkers of COPD. Accordingly, peripheral immune monitoring based on the above parameters may be useful to prevent disease progression in long-term smokers with normal LF and early COPD.
Copyright © 2024 Marques, Bocigas, Domingo, Francisco, Tarraso, Garcia-Sanjuan, Morcillo, Piqueras, Signes-Costa, González and Sanz.
Datos de la publicación
- ISSN/ISSNe:
- 1664-3224, 1664-3224
- Tipo:
- Article
- Páginas:
- 1441637-1441637
- PubMed:
- 39229275
Frontiers in Immunology FRONTIERS MEDIA SA
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- cigarette smoking; COPD; GOLD 1; endothelial dysfunction; platelets; leukocytes; systemic inflammation; cytokines
Financiación
Proyectos y Estudios Clínicos
CONTRATOS PREDOCTORALES DE FORMACIÓN EN INVESTIGACIÓN EN SALUD.
Investigador Principal: LUISA MARIA HUESO SOLER
FI19/00033 . INSTITUTO SALUD CARLOS III
ESTUDIO DE NUEVOS EJES DE QUIMIOCINAS COMO POTENCIALES DIANAS DE INTERVENCION EN LA OBESIDAD Y LA RESISTENCIA A LA INSULINA.
Investigador Principal: LAURA PIQUERAS RUIZ
PI21/00220 . INSTITUTO SALUD CARLOS III . 2022
CONTRATOS MIGUEL SERVET
Investigador Principal: VERA LUCÍA GOMES FRANCISCO
CP21/00025 . INSTITUTO SALUD CARLOS III . 2022
Cita
Key role of activated platelets in the enhanced adhesion of circulating leucocyte-platelet aggregates to the dysfunctional endothelium in early-stage COPD. Marques P, Bocigas I, Domingo E, Francisco V, Tarraso J, Garcia Y, Morcillo EJ et al. Frontiers in Immunology. 2024 agosto 19. 151441637-1441637. DOI:10.3389/fimmu.2024.1441637. PMID:39229275.
