Portal de investigación
Shared vulnerability and sex-dependent polygenic burden in psychotic disorders
Fecha de publicación:
Fecha Ahead of Print:
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Mitjans, M
- Papiol, S
- Fatjó-Vilas, M
- González-Peñas, J
- Acosta-Díez, M
- Zafrilla-López, M
- Costas, J
- Arango, C
- Vilella, E
- Martorell, L
- Bobes, J
- Crespo-Facorro, B
- González-Pinto, A
- Fananás, L
- Rosa, A
- Arias, B
Grupos y Plataformas de I+D+i
Abstract
Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sexdependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.
Copyright © 2024. Published by Elsevier B.V.
Datos de la publicación
- ISSN/ISSNe:
- 0924-977X, 1873-7862
- Tipo:
- Article
- Páginas:
- 49-54
- PubMed:
- 38941950
EUROPEAN NEUROPSYCHOPHARMACOLOGY ELSEVIER
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- Psychotic disorders; Polygenic scores; Shared genetics; Sex differences
Financiación
Cita
Shared vulnerability and sex-dependent polygenic burden in psychotic disorders. Mitjans M, Papiol S, Fatjó M, González J, Acosta M, Zafrilla M, Costas J et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2024 septiembre 01. 8649-54. DOI:10.1016/j.euroneuro.2024.04.017. PMID:38941950.
