Portal de investigación
Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters.
Autores de INCLIVA
Participantes ajenos a INCLIVA
- Losito, M
- Crisci, G
- Bertomeu-González, V
- Bayés-Genís, A
- Wahlberg, KJ
- Meyer, M
- Guazzi, M
Grupos y Plataformas de I+D+i
Abstract
AIMS: Emerging evidence suggests that smaller left ventricular volumes may identify subjects with lower cardiorespiratory fitness. Whether left ventricular size predicts functional capacity in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. This study aimed to explore the association between indexed left ventricular end-diastolic volume (iLVEDV) and maximal functional capacity, assessed by peak oxygen consumption (peakVO(2)), in stable outpatients with HFpEF. METHODS AND RESULTS: We prospectively analysed data from 133 consecutive stable outpatients who underwent cardiopulmonary exercise testing and echocardiography on the same day. Data were validated in a cohort of HFpEF patients from San Paolo Hospital, Milan, Italy. A multivariable linear regression assessed the association between iLVEDV and peakVO(2). The mean age was 73.2 ± 10.5 years, and 75 (56.4%) were women. The median iLVEDV, indexed left ventricular end-systolic volume, and left ventricular ejection fraction were 46 ml/m(2) (30-56), 15 ml/m(2) (11-19), and 66% (60-74%), respectively. The median peakVO(2) and percentage of predicted peakVO(2) were 11 ml/kg/min (9-13) and 64.1% (53-74.4), respectively. Adjusted linear regression analysis showed that smaller iLVEDV was associated with lower peakVO(2) (p = 0.0001). In the validation cohort, adjusted linear regression analysis showed a consistent pattern: a smaller iLVEDV was associated with a higher likelihood of reduced peakVO(2) (p = 0.004). CONCLUSIONS: In stable outpatients with HFpEF, a smaller iLVEDV was associated with a lower maximal functional capacity. These findings suggest a need for further studies to understand the pathophysiological mechanisms underlying these observations and to explore targeted treatment strategies for this patient subgroup.
© 2024 European Society of Cardiology.
Datos de la publicación
- ISSN/ISSNe:
- 1388-9842, 1879-0844
- Tipo:
- Article
- Páginas:
- 2544-2552
- DOI:
- 10.1002/ejhf.3401
- PubMed:
- 39078308
EUROPEAN JOURNAL OF HEART FAILURE WILEY
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- Heart failure with preserved ejection fraction; Left ventricular volumes; Peak oxygen consumption; Small hearts
Financiación
Proyectos y Estudios Clínicos
Congestión Renal en Insuficiencia Cardiaca Aguda y Síndrome Cardiorenal: Valoración No Invasiva Mediante Doppler Vascular Renal
Investigador Principal: JULIO NUÑEZ VILLOTA
PI20/00392 . INSTITUTO SALUD CARLOS III . 2021
Cita
de la Espriella R,Palau P,Losito M,Crisci G,Miñana G,Domínguez E,Bertomeu V,Bodí V,Sanchis J,Bayés A,Wahlberg KJ,Meyer M,Guazzi M,Núñez J. Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters. Eur. J. Heart Fail. 2024. 26. (12):p. 2544-2552. IF:10,800. (1).
Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters. de la Espriella R, Palau P, Losito M, Crisci G, Miñana G, Domínguez E, Bertomeu V et al. EUROPEAN JOURNAL OF HEART FAILURE. 2024 diciembre 01. 26 (12):2544-2552. DOI:10.1002/ejhf.3401. PMID:39078308.
